Table 4 Laboratory findings and serum biomarker levels of collagen disease patients with different clinical outcome in stable and AoDILD states

White Blood Cell count(X1000/ml)

8.5 (1.7)

10.4 (1.8)

0.138

11.4 (3.6)

13.0 (3.7)

0.279

Red Blood Cell count(X10⁶/ml)

4.3 (0.3)

3.9 (0.7)

0.043

4.1 (0.8)

4.4 (0.6)

0.069

Hemoglobin(g/dl)

13.7 (1.2)

11.7 (2.7)

0.043

12.7 (2.0)

12.9 (1.7)

0.108

Hematocrit(%)

41.5 (3.5)

35.6 (6.7)

0.043

40.1 (5.8)

39.2 (5.4)

0.917

Platelet(X1000/ml)

266.0 (62.5)

310.1 (131.2)

0.281

312.1 (119.0)

287.1 (102.4)

0.972

Albumin(g/dl)

3.9 (0.2)

3.0 (0.6)

0.068

4.1 (0.5)

3.6 (0.5)

0.005

Aspartate Aminotransferase(IU/l)

54.2 (60.6)

43.3 (34.2)

0.893

23.8 (6.8)

33.5 (14.0)

0.068

Alanine Aminotransferase(IU/l)

47.0 (55.2)

34.1 (38.9)

0.500

20.8 (7.8)

22.6 (11.1)

0.480

Lactate Dehydrogenase(IU/l)

234.0 (32.2)

361.8 (92.8)

0.138

232.5 (43.0)

346.2 (158.2)

0.039

Alkaline Phosphatase(IU/l)

320.2 (169.8)

224.9 (67.2)

0.144

238.2 (82.4)

268.5 (103.1)

0.221

γ-glutamyltransferase(IU/l)

42.4 (32.7)

179.1 (413.2)

0.419

38.1 (37.5)

42.8 (44.2)

0.142

Creatinine(mg/dl)

0.7 (0.1)

0.7 (0.2)

0.419

0.7 (0.1)

0.7 (0.1)

0.422

Blood Urea Nitrogen(mg/dl)

13.1 (2.5)

15.1 (5.2)

0.715

14.5 (2.7)

18.1 (4.3)

0.039

C-reactive protein(mg/dl)

0.8 (0.5)

12.0 (8.6)

0.080

3.8 (3.7)

7.3 (9.0)

0.311

KL-6(U/ml)

1364.1 (2423.4)

1565.4 (2498.4)

0.025

837.5 (936.0)

1173.8 (898.0)

0.017

Surfactant Protein-D(ng/ml)

136.8 (125.6)

196.0 (114.4)

0.036

87.1 (60.4)

169.6 (167.8)

0.203

TIMP-1(pg/ml)

231906 (68528)

346576 (72337)

0.080

197816 (49624)

260193 (96764)

0.084

TIMP-2(pg/ml)

118406 (27648)

105669 (20160)

0.345

122762 (20616)

100361 (17629)

0.012

TIMP-3(pg/ml)

10668 (6632)

15759 (12498)

0.043

17743 (12977)

15609 (4998)

0.790

MMP-3(pg/ml)

752633 (495718)

513110 (247738)

0.214

919436 (751496)

490655 (348157)

0.030

MMP-9(pg/ml)

1769108 (1012232)

3358493 (1977141)

0.011

3159443 (1634403)

2502127 (1229009)

0.140

Osteopontin(pg/ml)

13588 (9212)

51660 (44658)

0.008

15256 (14407)

16430 (9537)

0.551

Eotaxin 2(pg/ml)

4854 (4321)

4320 (5943)

0.110

4267 (2079)

4160 (4408)

0.096

IL-1RA(pg/ml)

224 (463)

657 (559)

0.086

112 (190)

236 (352)

0.445

IL-2Rα(pg/ml)

3827 (2213)

8408 (4328)

0.011

3492 (2072)

6865 (7488)

0.064

IL-6(pg/ml)

156 (339)

710 (1157)

0.066

69 (115)

140 (222)

0.328

MMP-1(pg/ml)

35772 (19709)

73909 (39388)

0.011

91449 (103647)

76538 (67816)

0.397

MMP-8 (pg/ml)

14814 (12583)

51014 (40613)

0.008

32889 (16905)

47213 (62177)

0.826

MMP-3/MMP-1

23.67 (18.54)

10.29 (8.39)

0.028

21.00 (18.50)

18.02 (23.73)

0.221