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Table 3 MBL2 genotypes and infections in 72 patients with ASCT during the 6 months of follow-up

From: Mannose-binding lectin gene variants and infections in patients receiving autologous stem cell transplantation

 

AA

AO/OO

RR (95% CI)

P-value*

 

Patients (%)

Patients (%)

  
 

n = 53

n = 19

  

Types of Infection

    

  -Pneumonia

2 (3.8)

2 (10.5)

2.8(0.4-18.4)

0.28

  -Sepsis

22 (41.5)

9 (47.4)

1.1 (0.6-2.0)

0.66

  -VCI

6 (11.3)

2 (10.5)

0.9 (0.2-4.2)

1.00

  -UTI

5 (9.4)

3 (15.8)

1.7 (0.4-6.3)

0.43

Major infection

6 (11.3)

5 (26.3)

2.32 (0.80-6.74)

0.15

Gram-positive infections

14 (26.4)

9 (47.4)

1.8 (0.9-3.4)

0.09

  -S. epidermidis

9 (17)

7 (36.8)

2.2 (0.9-5.0)

0.11

  -S. aureus

1 (1.9)

0 (0)

--

1.00

  -Other

    

Gram-negative infections

19 (35.8)

6 (31.6)

0.9 (0.4-1.9)

0.74

Viral infections

1 (1.9)

1 (5.3)

2.8 (0.2-42.4)

0.46

  -CMV

0 (0)

1 (5.3)

--

0.26

Fungal infections

1 (1.9)

4 (21.1)

11.5 (1.3-93.7)

0.016

  - Candida

1(1.9)

2 (10.5)

5.6 (0.5-58.1)

0.17

  - Aspergillus

0 (0)

1 (5.3)

--

0.26

  -Mucor

0 (0)

1 (5.3)

--

0.26

Nº deaths

4 (7.5)

3 (15.8)

2.1 (0.5-8.5)

0.37

Cause of death

    

  -Infection

0

3

--

0.05

  -Progression

3

0

--

 

  -Unknown (not infection)

1

0

--

 
  1. *Two-tailed Chi-squared test or Fisher exact test as corresponding.
  2. RR: risk ratio; CI: confidence interval.
  3. VCI: Venous catheter infection; UTI: Urinary tract infection.
  4. AA genotype: patients homozygous for wild-type structural allele (A).
  5. AO/OO genotype: patients heterozygous or homozygous for the B, C or D alleles.