Proposed model of T cell migration during the development of a secondary follicle. A. primary follicle. The CD7+/CD45RO+/CD69bright are disposed surrounding the primary follicle. B. After antigenic challenge the CD7+/CD45RO+/CD69bright cells migrate into the follicle, where they proliferate. C. The T cells originated into the germinal centre migrate out of the secondary follicle. The expression of CD69 diminishes going out from the internal part of the GC and it is lacking in cells outside of the follicle.