Reactivity of anti-cynomolgus CD38 mAbs. Top row: Flow cytometric profiles obtained by IF of parental NIH/3T3 (grey profile) and NIH/mac38 expressing cynomolgus CD38 (white profile) with OKT10 anti-human CD38 mAb and anti-cynomolgus CD38 mAb panel. Profiles obtained by staining both cell lines with CBT3G IgG control mAb completely overlap with the grey profile. Bottom row: Flow cytometric profiles obtained with NIH/hum38 and the indicated mAbs (white profile). Grey profile is the reactivity of CBT3G.