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Table 1 Mutagenic effect of the hAIDSc expression in yeast.

From: Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes

Strain

Plasmid

Mutation rates*

  

Canr × 10-7

Ade+ × 10-8

Trp+ × 10-8

Ura+ × 10-8

His+ × 10-8

wild-type

vector

2.5

24

4.1

4.0

2.4

  

1.2–6.5

21–34

1.3–14

2.2–6.6

1.9–2.9

 

hAIDSc

19

72

24

4.0

2.3

  

14–25

60–124

21–38

2.8–7.8

1.1–4.2

ung1::hygB

vector

13

210

134

23

3.0

  

10–31

190–290

110–170

20–35

1.9–4.5

 

hAIDSc

205

9700

5300

52

4.0

  

170–220

7500–12600

4400–6600

43–77

2–-7.1

  1. *Median mutation rates determined in 9–18 cultures. 95% confidence limits are shown below.
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BMC Immunology

ISSN: 1471-2172

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