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Figure 5 | BMC Immunology

Figure 5

From: Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens

Figure 5

Amino acid translation of the sequences of genes encoding human xenoantibodies. (A.) The amino acid translation of immunoglobulin heavy chain genes in the VH3 family encoding xenoantibodies at days 10 and 21 following exposure to porcine hepatocytes. The sequences at day 10 are expressed in germline configuration, however, the sequences at day 21 demonstrate the onset of mutations. Site-directed mutations were introduced into the germline gene in positions shown. (B.) The amino acid sequence of the genes encoding the light chain of a human xenoantibody that binds to the gal carbohydrate is shown compared with the closest germline progenitor, DPK9.

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BMC Immunology

ISSN: 1471-2172

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