Table 1 Neuroblastoma antigens identified by immune serum and SEREX.
Identity of cDNA SEREX hit | Accession | Characteristics | Ref |
|---|---|---|---|
DEK | BC055451 | p53 interaction, blocks apoptosis DNA binding/chromosomal organization, Proofreading of splicing Fused to can in leukemia | Wise-Draper '06 Waldman '04 Soares '06 Garcon '05 |
Hspa8, heat shock protein 8 (Hsc70) | NM_031165 | Promotes cell-cycle progression (w/cyclin D1) Binds/regulates dbl proto-oncogene | Diehl '03 Kauppinen '05 |
Fusip1, FUS interacting protein (Nssr, TASR) | BC0832082 | Neuronal Differentiation, modulates neuronal mRNA splicing Over-expressed in liposarcoma and leukemia | Liu '04 Fushimi '05 Clinton '02 |
Hmgb1, high mobility group box-1 | BC008565 | Inflammatory mediator DNA binding, architecture regulation | Andreason '02 Stott '06 |
Atp5c1, ATP synthase (mitochondrial F1 complex, gamma polypeptide 1) | BC010700 | ATP biosynthesis, upregulated in STI571-resistant leukemia | Hofmann '02 |
Sfrs5, splicing factor, arginine/serine-rich (SRp40, HRS) | BC085267 | Splicing factor, Akt substrate Apoptosis resistance | Patel '05 Tidd '03 |
Prpf38b, pre-mRNA processing factor (PRP38) | BC050900 | snRNP, required for spliceosome activity | Xie '98 |
Tuba1, tubulin, alpha 1 | BC085256 | Upregulated in carcinoma | Qi '05 |
Chn1, chimerin 1 | BC010825 | Neurotrophin target | Mizuno '04 |
Csnk2a1, casein kinase II, alpha 1 polypeptide | BC060742 | Phosphorylates/activates NFkappaB | Chantome '04 |
Mkks, McKusick-Kaufman syndrome protein | NM_021527 | Chaperonin, required for cytokenesis | Kim '05 |
Mier1, mesoderm induction early response 1 (Mi-er1, er1) | AK129405 | Fibroblast growth factor induced, HDAC1 interaction, transcription factor | Ding '03 Post '05 |
MTTR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | BC025942 | Mutations seen in neural tube defects Influences ALL susceptibility | Wilson '99 Gemmati '04 |
Psma6, proteasome subunit, alpha type 6 | NM_011968 | Upregulated in hepatocellular ca. | Cui '06 |
CD9 | NM_007657 | Cell surface tetraspannin, neuronal differentiation and neuroblastoma marker | Ishibashi '04 Komada '00 |
Chromogranin B, Chgb (secretogranin I) | NM_007694 | Present in neuroblastoma secretory vesicles | Goodall '97 |
Brd2, bromodomain containing 2 (NAT, Rnf3, Ring3, Fsrg1) | NM_001025387 | Binds to KSHV, LANA-1 protein Lymphomagenesis | Viejo-Borbolla '05 Greenwald '04 |
Crlf3, cytokine receptor-like factor 3 | AL591113 | Upregulated in skin cancer | Dang '06 |
Plod3, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (LH3) | NM_011962 | Collagen biosynthesis Upregulated in chemo resistant ca. | Rautavuoma '04 Cleator '05 |
Immt, inner membrane protein mitochondrial (HMP; P87; P89; P87/89) | AK038129 | Energy metabolism | John '05 |
Suv39h2, suppressor of variegation 3–9 homolog 2 | AF149205 | Epigenetic regulation of telomere length | Garcia-Cao '04 |
Serbp1, serpine1 mRNA binding protein | BC006030 | inferred function (by Gene Ontology) | Â |
Dus3l, dihydrouridine synthase 3-like | AY040840 | inferred function (by Gene Ontology) | Â |
Slc9a6, Solute carrier family 9 (Na+/H+ exchanger) | AK028350 | inferred function (by Gene Ontology) | Â |
2310042G06Rik | BC026968 | Riken cDNA, predicted protein | Â |