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Table 1 Physiochemical functionality of peptide side chains.

From: HLA class I supertypes: a revised and updated classification

Pocket specificity Associated amino acid residues
Acidic DE
Aliphatic LIVMQ
Aromatic FWY
Aromatic and aliphatic FWYLIVMQ
Aromatic and basic YRK
Aromatic and large hydrophobic FWYLIM
Basic RHK
Hydrophobic LIVMFWYA
Large hydrophobic FLIM
Proline P
Small AST
Small and aliphatic ATSVLIMQ
Small hydrophobic AV
Small, aliphatic and aromatic ASTVLIMQFWY