Goblet cell hyperplasia in ileum during S. mansoni infection. (A) S. mansoni egg content in the ileum of BALB/c (solid bar), IL-4Rα-/- (open bar) and IL-4/IL-13-/- (gray bar) mice at 8 weeks PI. Data are pooled from 2 to 4 individual experiments. Data are means of these experiments ± SEM. (B) Quantification of goblet cells per villus in ileum of naïve mice and 8 weeks PI from BALB/c (black bars), IL-4Rα-/- (open bar) and IL-4/IL-13-/- (gray bar). Data representative of three experiments are shown. * P < 0.05 (significantly different from naïve mice). (C) Photomicrograph of ileum from BALB/c, IL-4Rα-/- and IL-4/IL-13-/-. Representative pictures of ileum sections are shown from both naïve (i) and S. mansoni infected mice at 8 weeks PI (ii). Sections were stained with PAS to identify goblet cells. 100× magnification.