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Table 5 Regional differences in mRNA expression of CRS and cryptdins in small intestine of different mouse strains

From: Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract

 

C57BL/6

FVB

CRS1C

D = 1.8 × 106

D = 7.6 × 105

 

J = 2.6 × 106

J = 4.3 × 105

 

I = 2.5 × 106

I = 1.1 × 105

CRS4C

Not present

D = 1.2 × 105

  

J = 1.2 × 107

  

I = 2.5 × 107

Crypt1

D = 2.2 × 106

D = 3.3 × 106

 

J = 3.0 × 106

J = 3.2 × 106

 

I = 5.6 × 106

I = 2.2 × 106

Crypt4

Not present

D = 1.6 × 104

  

J = 1.1 × 105

  

I = 2.5 × 105

Crypt4 C57BL/6

D = 1.4 × 105

Not present

 

J = 4.7 × 106

 
 

I = 8.7 × 106

 
  1. Expression of CRS and cryptdin in different parts of the small intestine measured by qRT-PCR. Tissues pooled from three mice. D = duodenum, J = jejunum, I = ileum. Numbers denotes mRNA copy numbers per 10 ng RNA. Note that C57BL/6 mice lack CRS4C-1 to 3 and cryptdin 4 and display a unique cryptdin 4 variant.
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BMC Immunology

ISSN: 1471-2172

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