Table 1 Gene Ontology: biological process – up-regulated genes in tolerant hearts compared to syngeneic controls
From: Intragraft gene expression profile associated with the induction of tolerance
List Name | Total probes | Expected matches | Actual matches | Fold Enrichment | Binomial p-values |
|---|---|---|---|---|---|
response to biotic stimulus | 1353 | 22.64 | 61 | 2.69 | 1.16E-11 |
defense response | 1275 | 21.33 | 53 | 2.48 | 3.86E-09 |
immune response | 1166 | 19.51 | 50 | 2.56 | 3.87E-09 |
response to virus | 108 | 1.81 | 12 | 6.64 | 3.04E-07 |
response to pest, pathogen or parasite | 767 | 12.83 | 33 | 2.57 | 1.41E-06 |
response to other organism | 782 | 13.08 | 33 | 2.52 | 2.13E-06 |
response to stimulus | 3134 | 52.44 | 87 | 1.66 | 6.47E-06 |
JAK-STAT cascade | 66 | 1.1 | 8 | 7.24 | 1.49E-05 |
protein kinase cascade | 610 | 10.21 | 26 | 2.55 | 2.02E-05 |
response to pathogenic bacteria | 24 | 0.4 | 5 | 12.45 | 4.27E-05 |
regulation of DNA binding | 15 | 0.25 | 4 | 15.94 | 9.23E-05 |
I-kappaB kinase/NF-kappaB cascade | 223 | 3.73 | 13 | 3.48 | 1.18E-04 |
nuclear transport | 254 | 4.25 | 14 | 3.29 | 1.19E-04 |
nucleocytoplasmic transport | 276 | 4.62 | 14 | 3.03 | 2.79E-04 |
response to pathogen | 35 | 0.59 | 5 | 8.54 | 2.80E-04 |
maintenance of localization | 38 | 0.64 | 5 | 7.86 | 4.15E-04 |
response to bacteria | 59 | 0.99 | 6 | 6.08 | 4.63E-04 |
regulation of binding | 23 | 0.38 | 4 | 10.39 | 5.38E-04 |
response to stress | 1778 | 29.75 | 49 | 1.65 | 6.71E-04 |
T cell receptor signaling pathway | 14 | 0.23 | 3 | 12.81 | 1.48E-03 |
immune cell mediated cytotoxicity | 15 | 0.25 | 3 | 11.95 | 1.83E-03 |
negative regulation of protein import into nucleus | 15 | 0.25 | 3 | 11.95 | 1.83E-03 |
negative regulation of transcription factor import into nucleus | 15 | 0.25 | 3 | 11.95 | 1.83E-03 |
cytoplasmic sequestering of transcription factor | 15 | 0.25 | 3 | 11.95 | 1.83E-03 |
cytoplasmic sequestering of protein | 15 | 0.25 | 3 | 11.95 | 1.83E-03 |
negative regulation of nucleocytoplasmic transport | 16 | 0.27 | 3 | 11.21 | 2.23E-03 |
negative regulation of protein transport | 16 | 0.27 | 3 | 11.21 | 2.23E-03 |
inflammatory response | 311 | 5.2 | 13 | 2.5 | 2.57E-03 |
cholesterol metabolism | 140 | 2.34 | 8 | 3.42 | 2.61E-03 |
tyrosine phosphorylation of STAT protein | 17 | 0.28 | 3 | 10.55 | 2.67E-03 |
regulation of NF-kappaB import into nucleus | 17 | 0.28 | 3 | 10.55 | 2.67E-03 |
NF-kappaB import into nucleus | 17 | 0.28 | 3 | 10.55 | 2.67E-03 |
antigen receptor-mediated signaling pathway | 18 | 0.3 | 3 | 9.96 | 3.17E-03 |
nuclear export | 115 | 1.92 | 7 | 3.64 | 3.34E-03 |
cell killing | 19 | 0.32 | 3 | 9.44 | 3.71E-03 |
sterol metabolism | 149 | 2.49 | 8 | 3.21 | 3.82E-03 |
detection of stimulus | 63 | 1.05 | 5 | 4.74 | 4.12E-03 |
positive regulation of apoptosis | 368 | 6.16 | 14 | 2.27 | 4.18E-03 |
positive regulation of programmed cell death | 368 | 6.16 | 14 | 2.27 | 4.18E-03 |
detection of external stimulus | 41 | 0.69 | 4 | 5.83 | 4.85E-03 |
detection of abiotic stimulus | 41 | 0.69 | 4 | 5.83 | 4.85E-03 |
DNA metabolism | 1205 | 20.16 | 33 | 1.64 | 4.94E-03 |
viral genome replication | 42 | 0.7 | 4 | 5.69 | 5.29E-03 |
RNA export from nucleus | 97 | 1.62 | 6 | 3.7 | 5.94E-03 |
nucleic acid transport | 97 | 1.62 | 6 | 3.7 | 5.94E-03 |
RNA transport | 97 | 1.62 | 6 | 3.7 | 5.94E-03 |
establishment of RNA localization | 97 | 1.62 | 6 | 3.7 | 5.94E-03 |
caspase activation | 44 | 0.74 | 4 | 5.43 | 6.25E-03 |
response to drug | 44 | 0.74 | 4 | 5.43 | 6.25E-03 |
positive regulation of caspase activity | 44 | 0.74 | 4 | 5.43 | 6.25E-03 |
lipid transport | 131 | 2.19 | 7 | 3.19 | 6.78E-03 |
RNA localization | 101 | 1.69 | 6 | 3.55 | 7.20E-03 |