Skip to main content
Figure 2 | BMC Immunology

Figure 2

From: Insulin-like growth factor I promotes cord blood T cell maturation through monocytes and inhibits their apoptosis in part through interleukin-6

Figure 2

Effects of IGF-I on PHA-induced changes in CD45 isoform expression on CD4+ T helper cells and CD8+ cytotoxic T cells in (a) CBMC culture; and, (b) purified CD3+ T cell culture. CBMC (a) or CD3+ T cells (b) were incubated with PHA (1 μg/ml) ± IGF-I (100 ng/ml) for 6 days. IGF-I significantly promoted the PHA-induced down-regulation of naïve T cells (CD45RA+CD45RO-) and up-regulation of mature T cells (CD45RA-CD45RO+). Results shown are from 8 and 14 independent cases of CBMC and CD3+ T cells respectively.

Back to article page

BMC Immunology

ISSN: 1471-2172

Contact us