Figure 1

Genomic region of the QTL on chromosome 1 based three congenic strains. The top panel represents the location of initial mapping of the QTL for arthritis previously identified using the F2 generation. The numbers of the left of the vertical bar indicates the LOD score. The bottom panel is a diagrammatic representation of the transferred genomic regions (Red boxes) from DBA/1^−/− into BALB/c^−/− after the generation of 2 congenic strains. The genomic region from DBA/1 in BALB.D1-1^−/− is flanked by two markers, D1Mit55 and D1Mit209. The transferred genomic regions (Black boxes) from DBA/1^−/− into BALB/c^−/− in congenic strain BALB.D1-2^−/− is flanked by marker D1Mit359 and the distal end of the chromosome. The two red cycled white boxes indicate where the borders of the QTL are not clearly defined. The genomic region from BALB/c in D1BALB-1^−/− is flanked by markers, D1Mit400/506 at the distal end.