Figure 3

Functional interaction network of Guillain-Barre Syndrome associated genes and vaccine ingredients. Genes associated with GBS are represented by circles. “Linker” genes added interconnect the network are represented as diamonds. Red triangles represent vaccine ingredients that interact with genes in the network. Genes highlighted in yellow are present in both the KEGG Influenza A pathway and were significantly up or down regulated following influenza vaccination [39]. The circles of similar color are “modules” from clustering based on network topology. Full details of all genes in each module are provided in Additional file 6: Table S6.