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Table 4 Dose effects of gene–gene and gene–environment interactions on susceptibility to LTBI and PTB

From: Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case–control study

Cytokines SNP position Genotypes LTBI.vs.HC PTB.vs.LTBI
Gene Gene*BCG Gene Gene*BCG
IFNγ (+874)T- > A Additive 0.092 0.093 0.264 0.093
   Dominant 0.616 0.193 0.010* 0.117
   Recessive 0.003* 0.277 0.552 0.405
   Multiplicative 0.174 0.382 0.976 0.979
IL-10 (−1082)G- > A Additive 0.015 0.909 0.540 0.466
   Dominant 0.485 0.837 0.208 0.507
   Recessive 0.880 0.775 0.098 0.709
   Multiplicative 0.423 0.749 0.134 0.411
TNFα (−308)A- > G Additive 0.845 0.722 0.945 0.873
   Dominant 0.995 1.000 0.995 0.999
   Recessive 0.072 0.326 0.144 0.700
   Multiplicative 1.000 0.999 0.995 0.994
IL2   Additive 0.815 0.909 0.437 0.485
   Dominant 0.485 0.837 0.845 0.613
   Recessive 0.881 0.775 0.253 0.223
   Multiplicative 0.423 0.749 0.577 0.397
  1. Notes: HC, healthy controls; LTBI, subjects with latent tuberculosis infection; PTB, patients with pulmonary tuberculosis; INF-γ, interferon γ; IL-10, interleukin 10; TNF-α, tumor necrosis factor α; IL-2, interleukin 2.
  2. *p < 0.05.