Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case–control study

Table 4 Dose effects of gene–gene and gene–environment interactions on susceptibility to LTBI and PTB

Cytokines	SNP position	Genotypes	LTBI.vs.HC		PTB.vs.LTBI
Cytokines	SNP position	Genotypes	Gene	*GeneBCG**	Gene	*GeneBCG**
IFNγ	(+874)T- > A	Additive	0.092	0.093	0.264	0.093
		Dominant	0.616	0.193	0.010*	0.117
		Recessive	0.003*	0.277	0.552	0.405
		Multiplicative	0.174	0.382	0.976	0.979
IL-10	(−1082)G- > A	Additive	0.015	0.909	0.540	0.466
		Dominant	0.485	0.837	0.208	0.507
		Recessive	0.880	0.775	0.098	0.709
		Multiplicative	0.423	0.749	0.134	0.411
TNFα	(−308)A- > G	Additive	0.845	0.722	0.945	0.873
		Dominant	0.995	1.000	0.995	0.999
		Recessive	0.072	0.326	0.144	0.700
		Multiplicative	1.000	0.999	0.995	0.994
IL2		Additive	0.815	0.909	0.437	0.485
		Dominant	0.485	0.837	0.845	0.613
		Recessive	0.881	0.775	0.253	0.223
		Multiplicative	0.423	0.749	0.577	0.397

Notes: HC, healthy controls; LTBI, subjects with latent tuberculosis infection; PTB, patients with pulmonary tuberculosis; INF-γ, interferon γ; IL-10, interleukin 10; TNF-α, tumor necrosis factor α; IL-2, interleukin 2.
*p < 0.05.

ISSN: 1471-2172