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Table 1 HLA class I restricted epitopes (I)

From: Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV

Number Residues Sequence HLA Reference
HBsEC-1 20–28 FLLTRILTI A*02:01, 02:05, 02:06 [13]
HBsEC-2 88–96 LLCLIFLLV A2 [9, 14]
HBsEC-3 95–104 LVLLDYQGML A2 [8]
HBsEC-4 172–180 WLSLLVPFV A*02:01, 02:02,02:03,02:05, 02:06 [6, 8, 9, 14, 15]
HBsEC-5 207–216 SIVSPFIPLL A2 [14]
HBsCP-6b 169–176 FLGPLLVL A2a  
  180–187    
  179–188    
HBsCP-7b 72–79 LLGWSPQA A2a  
  61–68    
  71–78    
HBsCP-8b 259–266 LLLCLIFL A2a  
  248–255    
  258–265    
HBsCP-9b 333–370 FLWEWASA A2a  
  332–339    
  322–329    
HBsCP-10b 129–136 PAGGSSSG A2a  
  140–147    
  139–146    
HBcEC-11 18–27 FLPSDFFPSV A*02:01, 02:05, 02:06 [6, 8, 9, 1417]
HBcEC-12 88–96 YVNVNMGLK A11 [18]
HBcEC-13 107–115 CLTFGRETV A2 [8]
HBcEC-14 117–125 EYLVSFGVW A24 [19]
HBcEC-15 139–148 ILSTLPETTV A2 [8]
HBcCP-16 141–148 TLPETTVV A2  
HBcCP-17 160–168 PSPRRRRS A2  
HBcCP-18 64–71 LMTLATWV A2  
HBcCP-19 29–36 LLDTASAL A2  
HBcCP-20 107–114 LTFGRETV A2  
  1. Name and amino acid position of the 20 epitopes. HLA genotype indicates which genotypes were tested in previous studies (HBsEC1-5 and HBcEC11-15), or which genotypes we stratified for in the in silico analysis (HBsCP6-10 and HBcCP16-20)
  2. HBsEC HBsAg experimentally confirmed, HBsCP HBsAg computer predicted, HBcEC HBcAg experimentally confirmed, HBcCP HBcAg computer predicted
  3. aall subtypes
  4. bdifferences of sequence position among HBV genotypes was observed for in silico prediction of HBsAg