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Table 2 HLA class I restricted epitopes (II)

From: Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV

Number Response AHB Response CHB K D Reference
HBsEC-1 14/23 N/A N/A [13]
HBsEC-2 6/13 1/15 N/A [9, 14]
HBsEC-3 N/A 16/17 N/A [8]
HBsEC-4 42/56 5/33 N/A [6, 8, 9, 14, 15]
HBsEC-5 2/4 0/12 N/A [14]
HBsCP-6    <50 nM  
HBsCP-7    <50 nM  
HBsCP-8    <50 nM  
HBsCP-9    <50 nM  
HBsCP-10    >500 nM  
HBcEC-11 41/59 9/30 50–10,000 nM [6, 8, 9, 1417]
HBcEC-12 N/A 1/1 N/A [18]
HBcEC-13 N/A 2/5 >50 nM [8]
HBcEC-14 7/12 0/11 >500 nM [19]
HBcEC-15 N/A 15/18 >50 nM [8]
HBcCP-16    <50 nM  
HBcCP-17    >500 nM  
HBcCP-18    <50 nM  
HBcCP-19    <50 nM  
HBcCP-20    50–500 nM  
  1. All K D values are in silico predictions by NetMHC version 3.2 8mer predictions. HBsEC: HBsAg experimentally confirmed; HBsCP: HBsAg computer predicted; HBcEC: HBcAg experimentally confirmed; HBcCP: HBcAg computer predicted. N/A: Not available, AHB and CHB referres to number of responders in previous studies of acute hepatitis B (AHB) and chronic hepatitis B patients (CHB)