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Table 2 HLA class I restricted epitopes (II)

From: Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV

Number

Response AHB

Response CHB

K D

Reference

HBsEC-1

14/23

N/A

N/A

[13]

HBsEC-2

6/13

1/15

N/A

[9, 14]

HBsEC-3

N/A

16/17

N/A

[8]

HBsEC-4

42/56

5/33

N/A

[6, 8, 9, 14, 15]

HBsEC-5

2/4

0/12

N/A

[14]

HBsCP-6

  

<50 nM

 

HBsCP-7

  

<50 nM

 

HBsCP-8

  

<50 nM

 

HBsCP-9

  

<50 nM

 

HBsCP-10

  

>500 nM

 

HBcEC-11

41/59

9/30

50–10,000 nM

[6, 8, 9, 1417]

HBcEC-12

N/A

1/1

N/A

[18]

HBcEC-13

N/A

2/5

>50 nM

[8]

HBcEC-14

7/12

0/11

>500 nM

[19]

HBcEC-15

N/A

15/18

>50 nM

[8]

HBcCP-16

  

<50 nM

 

HBcCP-17

  

>500 nM

 

HBcCP-18

  

<50 nM

 

HBcCP-19

  

<50 nM

 

HBcCP-20

  

50–500 nM

 
  1. All K D values are in silico predictions by NetMHC version 3.2 8mer predictions. HBsEC: HBsAg experimentally confirmed; HBsCP: HBsAg computer predicted; HBcEC: HBcAg experimentally confirmed; HBcCP: HBcAg computer predicted. N/A: Not available, AHB and CHB referres to number of responders in previous studies of acute hepatitis B (AHB) and chronic hepatitis B patients (CHB)