Fig. 5

Serglycin-deficiency leads to increased muscle tissue larvae burden in T. spiralis infected mice. Larvae burden 5 weeks post infection was assesed in infected WT and SG^−/− mice muscle tissue stained with Giemsa. Representative pictures of cheek masseter muscle from SG^−/− (a) and WT (b) mice stained with Giemsa, with quantification of total larvae burden (c), area of inflammatory foci (d) and eosiniphil number in the inflammatory foci (e) are shown. Area of inflammation was determined with Nikon NIS software. Data obtained from one experiment with control mice (N = 3) and infected mice (N = 7 for WT and N = 6 for SG^−/−) for each genotype is shown in c and d. N = 5 for WT and N = 4 for SG^−/− in e. Data is expressed as mean values and significant differences between WT and SG^−/− mice are indicated in the figure. *P ≤0.05, **P <0.001 versus infected WT mice