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Table 2 Statistical analysis of promiscuous peptides across every two supertypes

From: HLAsupE: an integrated database of HLA supertype-specific epitopes to aid in the development of vaccines with broad coverage of the human population

 

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

T

U

V

W

X

A

--

193

152

81

131

28

98

22

207

295

32

24

319

61

         

B

9

--

119

68

114

71

100

45

115

156

31

23

29

37

 

1

   

1

   

C

3

4

--

20

62

7

57

16

96

112

34

16

47

112

    

5

4

4

2

4

D

5

16

3

--

44

8

10

12

48

58

8

6

101

7

         

E

3

15

3

11

--

71

58

20

134

227

21

8

14

16

         

F

 

3

  

1

--

65

6

19

79

7

6

 

25

    

1

 

1

1

1

G

 

3

   

1

--

44

34

157

35

20

4

46

         

H

1

2

  

1

1

 

--

26

33

3

10

9

      

1

   

I

 

1

1

2

2

   

--

192

20

8

25

27

         

J

1

2

 

3

3

    

--

32

8

44

44

    

1

 

1

  

K

 

3

  

2

 

2

   

--

20

9

1

         

L

4

  

5

    

1

 

1

--

2

5

         

M

10

1

 

2

        

--

4

         

N

2

1

3

 

1

    

1

   

--

         

O

  

1

        

2

  

--

192

99

200

310

168

270

285

265

P

              

2

--

104

336

341

177

292

320

292

Q

              

1

3

--

138

127

92

134

108

100

R

          

1

   

1

43

4

--

476

234

402

403

380

T

 

19

2

10

5

1

        

9

17

 

26

--

782

1714

1550

1310

U

 

9

 

4

1

         

6

7

1

9

53

--

746

724

583

V

 

10

1

9

3

         

5

18

1

12

171

51

--

1361

1088

W

 

6

 

1

1

         

7

8

 

13

93

38

71

--

1089

X

 

2

 

2

          

5

10

 

1

87

7

32

34

--

  1. Promiscuous peptides that can be presented by multiple HLA molecules within different supertypes were collected, and a statistical analysis of these promiscuous data across every two supertypes was performed. Statistics on promiscuous epitopes are shown in the lower triangle, and statistics on promiscuous binding peptides are shown in the upper triangle. The values in the table indicate the numbers of peptides that can be presented by HLA molecules within the two supertypes indicated in the row and column headers. The supertype names are presented in capital letters according to the labels in Table 1