Fig. 1
From: Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice
Similar levels of human immune cell reconstitution between NRG mice engrafted intravenously as adults or intrahepatically as pups with human CD34+ cells. NRG mice were engrafted with human CD34+ cells either intravenously as adults or intrahepatically as newborn pups. At 22 to 28 weeks after transplantation, spleen, bone marrow, blood and thymuses were taken from the engrafted NRG mice and examined for human and mouse CD45 expression. Representative flow plots of human and mouse CD45 expression in isolated tissues shown in (a) and (c), respectively. The percentage of human CD45+ cells in NRG engrafted mice are graphically represented in (b). Percentage of mouse CD45+ cells in NRG engrafted mice are graphically represented in (d). n = 3; *p < 0.05