Fig. 1

Weight loss is greater in cPLA₂α^−/− than cPLA₂α^+/+ mice during C. albicans lung infection. Body weight of cPLA₂α^−/− (KO, open symbols) and cPLA₂α^+/+ (WT, closed symbols) mice was monitored after intratracheal instillation of saline (squares) or C. albicans (CA, circles) using an inoculum of (a) 10⁷ or (b) 10⁶ CA. Body weight is expressed as the % of the weight determined just prior to instillation of C. albicans or saline (n = 8–13 mice/group, from 4–6 independent experiments). *P < 0.05 compared to cPLA₂α^+/+ with saline; #P < 0.05 compared to cPLA₂α^−/− with saline; **P < 0.05 compared to cPLA₂α^+/+ with CA. c Survival of female cPLA₂α^−/− (KO, open symbols) and cPLA₂α^+/+ (WT, closed symbols) mice was monitored after intratracheal administration of 5 x 10⁶ CFU C. albicans (6 mice/group)