Fig. 4

B cell specific conformational antigenic determinants (AI) and linear epitopes (AII). (AI, AII) In each case domains of E protein are presented by different colors (i.e. domain I red, domain II silver and domain III green). (B) Representative Epitope pairs (BI for G388K and BII for W396R) for comparison of main chain topology of wild-type (blue) and mutant-type (red). The wild-type (yellow) and mutant (cyan) type residues are shown in stick formats. Each of this peptide structure was generated using PEP-FOLD [43] followed by normalization and fixation of charge and potential. RMSD of mutant structure was computed in reference to its wild-type. F-L: Fusion loop; RGD-L: RGD loop