Fig. 1

A short-term treatment with anti-IL-7Rα antibodies delays and prevents diabetes in NOD mice. a Experimental design outline: 11-week old prediabetic female NOD mice received four doses of 0.5 mg anti-IL-7Rα (n = 10) or rat IgG (n = 10) antibodies on days 0, 5, 15 and 19. Blood was drawn at day 21 and 35 and T cell populations were analyzed by flow cytometry, and, b diabetes incidence was followed in mice that received anti-IL-7Rα antibodies (black circles) or rat IgG (white circles) measuring urine and blood glucose levels until 32 weeks of age. Data were pooled from two independent experiments (n = 20). P value is indicated in the figure