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Table 3 Clinical characteristics of chronic ITP patients with IFN-γ and IFN-γR

From: The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

  IFN-γ AA IFN-γ non-AA   IFN-γR AA IFN-γR non-AA  
N (%) N (%) P value OR 95% CI N (%) N (%) P value OR 95% CI
No. of patients (%) 108 (85.7) 18 (14.3)     115 (91.3) 11 (8.7)    
Female patients, no. of cases (%) 82 (75.9) 10 (55.6) 0.09 2.52 0.90–7.06 84 (73.0) 8 (72.7) 1.00 1.02 0.25–4.08
Age (years) at diagnosis, range (median) 2.4–81.9 (49.0) 5.0–82.3 (37.7) 0.25    2.4–82.3 (46.0) 19.9–79.0 (60.9) 0.20   
Platelet count (×109/L) at diagnosis, mean ± SD 30.8 ± 24.9 21.9 ± 20.7 0.15    29.9 ± 24.6 25.8 ± 22.8 0.60   
 Mild thrombocytopenia, no. of cases (%) 26 (24.1) 2 (11.1) 0.36 2.54 0.55–11.77 26 (22.6) 2 (18.2) 1.00 1.32 0.27–6.47
 Moderate thrombocytopenia, no. of cases (%) 24 (22.2) 4 (22.2) 1.00 1.00 0.30–3.32 25 (21.7) 3 (27.3) 0.71 0.74 0.18–3.00
 Severe thrombocytopenia, no. of cases (%) 35 (32.4) 5 (27.8) 0.79 1.25 0.41–3.77 37 (32.2) 3 (27.3) 1.00 1.27 0.32–5.05
 Very severe thrombocytopenia, no. of cases (%) 23 (21.3) 7 (38.9) 0.13 0.43 0.15–1.22 27 (23.5) 3 (27.3) 0.72 0.82 0.20–3.30
Minimum platelet count (×109⁄L), mean ± SD 19.4 ± 18.9 12.9 ± 10.7 0.045    18.2 ± 17.6 21 ± 23.1 0.63   
Bleeding tendency, no. of cases (%) 69 (63.9) 11 (61.1) 0.80 1.13 0.40–3.14 73 (63.5) 7 (63.6) 1.00 0.99 0.28–3.59