Table 3 Clinical characteristics of chronic ITP patients with IFN-γ and IFN-γR
IFN-γ AA | IFN-γ non-AA | IFN-γR AA | IFN-γR non-AA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | (%) | N | (%) | P value | OR | 95% CI | N | (%) | N | (%) | P value | OR | 95% CI | |
No. of patients (%) | 108 | (85.7) | 18 | (14.3) | 115 | (91.3) | 11 | (8.7) | ||||||
Female patients, no. of cases (%) | 82 | (75.9) | 10 | (55.6) | 0.09 | 2.52 | 0.90–7.06 | 84 | (73.0) | 8 | (72.7) | 1.00 | 1.02 | 0.25–4.08 |
Age (years) at diagnosis, range (median) | 2.4–81.9 | (49.0) | 5.0–82.3 | (37.7) | 0.25 | 2.4–82.3 | (46.0) | 19.9–79.0 | (60.9) | 0.20 | ||||
Platelet count (×109/L) at diagnosis, mean ± SD | 30.8 | ± 24.9 | 21.9 | ± 20.7 | 0.15 | 29.9 | ± 24.6 | 25.8 | ± 22.8 | 0.60 | ||||
Mild thrombocytopenia, no. of cases (%) | 26 | (24.1) | 2 | (11.1) | 0.36 | 2.54 | 0.55–11.77 | 26 | (22.6) | 2 | (18.2) | 1.00 | 1.32 | 0.27–6.47 |
Moderate thrombocytopenia, no. of cases (%) | 24 | (22.2) | 4 | (22.2) | 1.00 | 1.00 | 0.30–3.32 | 25 | (21.7) | 3 | (27.3) | 0.71 | 0.74 | 0.18–3.00 |
Severe thrombocytopenia, no. of cases (%) | 35 | (32.4) | 5 | (27.8) | 0.79 | 1.25 | 0.41–3.77 | 37 | (32.2) | 3 | (27.3) | 1.00 | 1.27 | 0.32–5.05 |
Very severe thrombocytopenia, no. of cases (%) | 23 | (21.3) | 7 | (38.9) | 0.13 | 0.43 | 0.15–1.22 | 27 | (23.5) | 3 | (27.3) | 0.72 | 0.82 | 0.20–3.30 |
Minimum platelet count (×109⁄L), mean ± SD | 19.4 | ± 18.9 | 12.9 | ± 10.7 | 0.045 | 18.2 | ± 17.6 | 21 | ± 23.1 | 0.63 | ||||
Bleeding tendency, no. of cases (%) | 69 | (63.9) | 11 | (61.1) | 0.80 | 1.13 | 0.40–3.14 | 73 | (63.5) | 7 | (63.6) | 1.00 | 0.99 | 0.28–3.59 |