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Fig. 5 | BMC Immunology

Fig. 5

From: Generation of populations of antigen-specific cytotoxic T cells using DCs transfected with DNA construct encoding HER2/neu tumor antigen epitopes

Fig. 5

Results of the cytotoxicity assay. a Cytotoxic activity of cultures of HER2-specific T cells against the MCF-7 cell line (n = 6). Control MCF-7 – Control over spontaneous death of the target cells. E75-specific cells – Cell culture after magnetic-activated cell sorting at HER2/neu epitope E75 (KIFGSLAFL). E88-specific cells – Cell culture after magnetic-activated cell sorting at HER2/neu epitope E88 (RLLQETELV). *p < 0.05, significant difference compared with the control. Data are presented as median and interquartile range. b Scatter plot of the experimental sample (PI-labeled coculture of MCF-7 cells and HER2-specific cells). c Scatter plot of the control over spontaneous death of target cells (PI-labeled MCF-7 cells). d Scatter plot showing the distribution of events from MCF-7 region in control sample contained MCF-7 cells labeled with FITC but not labeled with PI

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BMC Immunology

ISSN: 1471-2172

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