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Fig. 5 | BMC Immunology

Fig. 5

From: JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation

Fig. 5

TOFA suppressed Ifit3 and Isg15 expression in BWF1 mice and IFIT3 expression was also inhibited after immunosuppressive treatment. (a) Ifit3 and Isg15 expression associated with the IFN-signalling pathway in splenic CD4+ T cells from BWF1 mice. Each represents [TOFA (n = 8); TOFA + DEXA (n = 15); DEXA (n = 5); and control (n = 8)]. *p < 0.05 (vs. control mice). (b) IFIT3 expression in each CD3+ T cell population from SLE patients (n = 9) pre- and post-immunosuppressive treatment including steroid. *p < 0.05 (vs. pre-treatment)

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BMC Immunology

ISSN: 1471-2172

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