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Fig. 5 | BMC Immunology

Fig. 5

From: Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised

Fig. 5

Treatment with effector specific membrane permeable cAMP analogues is sufficient to increase TREG suppressive function. TREG cells were treated with either PKA- or EPAC1- specific cyclic-AMP for 30 min. cAMP-treated TREG cells were co-cultured with untreated non-sensitized naive Th cells using artificial Th cell activation (anti-CD3 and anti-CD28) for 72 h. Th cell proliferation was assessed using 3H–thymidine incorporation. a non-sensitized TREG cells. (n = 7–10) *P ≤ 0.02 between groups where indicated. b OVA-sensitized TREG cells. (n = 7–10) *P ≤ 0.04 between groups where indicated. All data are shown as mean +/− SEM of triplicates of seven independent experiments

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BMC Immunology

ISSN: 1471-2172

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