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Table 4 Comparison of IF intensity grades and serum levels of IgA between IgAN and MN

From: A pilot and comparative study between pathological and serological levels of immunoglobulin and complement among three kinds of primary glomerulonephritis

 

Parameters

IgA pathological grade

P value

Ptrend

Neg

+

++

IgAN

N(female)

–

32(9)

56(21)

0.257

–

Age

–

41.8(36.9–46.6)

36.2(33.5–38.8)

0.039

0.028

Un

–

6.46(5.57–7.34)

6.17(5.27–7.06)

0.288

0.669

Cr

–

120.5(102.7–138.2)

106.6(91.3–121.9)

0.082

0.251

eGFR

–

74.6(62.8–86.5)

88.2(79.5–96.9)

0.051

0.065

sIgA

–

272.5(240.0–304.9)

328.3(299.5–357.1)

0.007

0.016

MN

N(female)

91(37)

5(3)

4(1)

0.556

–

Age

48.7(45.4–51.9)

42.6(29.3–55.9)

45.3(34.1–56.5)

0.462

0.421

Un

5.50(4.93–6.08)

5.61(3.27–7.96)

5.05(3.10–7.00)

0.815

0.822

Cr

75.4(70.4–80.5)

99.9(46.4–153.5)

62.7(40.4–85.0)

0.212

0.908

eGFR

101.2(96.3–106.2)

83.5(33.0–134.0)

117.5(99.9–135.0)

0.183

0.693

sIgA

218.9(200.1–237.7)

285.0(218.0–352.0)

190.5(79.4–301.6)

0.092

0.847

  1. Pathological grades were IF intensity grades of IgG, IgM,IgA, C3 and C4 were defined as following: Neg: negative, +: positive, ++: strong positive. P value showed difference among Neg, positive (+) and (++)(analyzed by nonparametric tests-Kruskal-Wallis H test). Ptrend showed serum immunoglobulin or compliment trends with their enhanced Pathological grade. P and Ptrend values under 0.05 were considered as cut-off values as statistically significant differences