Table 1 Comparison of immune activities between the lower-TMB and the higher-TMB subtypes of cancers
From: Correlate tumor mutation burden with immune signatures in human cancers
Immune signatures | Genes upregulated in the lower-TMB subtype of various cancer types a | Genes upregulated in the higher-TMB subtype of various cancer types b | Cancer types in which the immune signature is upregulated in the lower-TMB subtype | Cancer types in which the immune signature is upregulated in the higher-TMB subtype |
|---|---|---|---|---|
Treg | ADPRH, IL1R1, KSR1, SOCS2, JAK1, NFAT5, SSH1 | TFRC, ETV7, ADAT2, PD-L1, IL12RB2 | HNSC, STAD, CHOL, UVM, PRAD, ACC, THCA, LUSC, ESCA, DLBC, KIRP, LIHC | THYM |
immune checkpoint | C10orf54, CD200, CD40LG, ADORA2A, TNFSF14, BTLA, CD160, CD44, CD48, CD28, VTCN1, CD200R1, NRP1, TMIGD2, ICOS, TNFSF15 | LAG3, CD80, TNFSF9, IDO1, CD70, KIR3DL1, CTLA4, PD-1, PD-L1, PD-L2, TIGIT, TNFRSF9 | TGCT, KIRC, HNSC, ACC, THCA, LIHC, THYM | CESC, COAD, UCEC, BLCA |
immune cell infiltrate | ENG, CD45RO, CD20, CD1A, TPSB2, PDPN, CXCR5, IL3RA, CSF3, CD3, CD57 | CD68 | PRAD, KIRP, TGCT, KIRC, DLBC, ACC, HNSC, THCA, STAD, LUAD, THYM, LIHC | UCEC |
TILs | GIMAP6, CFH, ITGA4, FAM65B, GVIN1, ARHGAP15, ARHGAP25, GIMAP4, GIMAP7, GPSM3, IL16, PIK3CD, PRKCB, SELL, GIMAP5, INPP5D, NLRC3, PRKCQ, TRAT1 | XCL1, SPNS1, VAMP5, TIGIT | TGCT, KIRC, DLBC, HNSC, STAD, ACC, THCA, LIHC, THYM | CESC, UCEC, COAD |
CTA | CEP55, KIF2C, TTK, OIP5, CASC5, NUF2, MAGEA, MAGEB, MAGEC, PAGE, NY-ESO-1, PRAME | RGS22, TDRD6, TMEM108 | COAD, UVM, THCA, UCEC | BRCA, LUAD, BLCA, HNSC, THYM, LIHC, LAML, ACC, SARC, SKCM, CESC, LGG, LUSC |
HLA | HLA-J, DOA, DOB, DPB1, DQA1, DQB2 | NA | LIHC, HNSC, ACC, PRAD, LUAD | CESC, COAD, LGG, SKCM |
CCR | TNFAIP8L3, CCL14, CX3CR1, CCL21, IL1R1, IL33, CCL19, CCR6, IL16, IL17D, TGFB2, TGFBR2, BMP3, CXCL12, TNFSF8 | ILF2, CXCL9, CXCL10, CXCL11, ILKAP, IFNG | LUSC, DLBC, UVM, TGCT, PRAD, LUAD, KIRC, ACC, HNSC, THCA, STAD, LIHC | THYM |
pro-inflammatory | IL12A, IL12B, PRF1, TBX21 | CXCL9, CXCL10, IFNG, GZMB, CXCL13, STAT1, IRF1, GNLY | KIRC, TGCT, ACC, HNSC, KIRP, THCA | CESC, COAD, UCEC, BLCA, LUAD, BRCA, STAD, LGG, SKCM, SARC |