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Table 1 Comparison of immune activities between the lower-TMB and the higher-TMB subtypes of cancers

From: Correlate tumor mutation burden with immune signatures in human cancers

Immune signatures Genes upregulated in the lower-TMB subtype of various cancer types a Genes upregulated in the higher-TMB subtype of various cancer types b Cancer types in which the immune signature is upregulated in the lower-TMB subtype Cancer types in which the immune signature is upregulated in the higher-TMB subtype
Treg ADPRH, IL1R1, KSR1, SOCS2, JAK1, NFAT5, SSH1 TFRC, ETV7, ADAT2, PD-L1, IL12RB2 HNSC, STAD, CHOL, UVM, PRAD, ACC, THCA, LUSC, ESCA, DLBC, KIRP, LIHC THYM
immune checkpoint C10orf54, CD200, CD40LG, ADORA2A, TNFSF14, BTLA, CD160, CD44, CD48, CD28, VTCN1, CD200R1, NRP1, TMIGD2, ICOS, TNFSF15 LAG3, CD80, TNFSF9, IDO1, CD70, KIR3DL1, CTLA4, PD-1, PD-L1, PD-L2, TIGIT, TNFRSF9 TGCT, KIRC, HNSC, ACC, THCA, LIHC, THYM CESC, COAD, UCEC, BLCA
immune cell infiltrate ENG, CD45RO, CD20, CD1A, TPSB2, PDPN, CXCR5, IL3RA, CSF3, CD3, CD57 CD68 PRAD, KIRP, TGCT, KIRC, DLBC, ACC, HNSC, THCA, STAD, LUAD, THYM, LIHC UCEC
TILs GIMAP6, CFH, ITGA4, FAM65B, GVIN1, ARHGAP15, ARHGAP25, GIMAP4, GIMAP7, GPSM3, IL16, PIK3CD, PRKCB, SELL, GIMAP5, INPP5D, NLRC3, PRKCQ, TRAT1 XCL1, SPNS1, VAMP5, TIGIT TGCT, KIRC, DLBC, HNSC, STAD, ACC, THCA, LIHC, THYM CESC, UCEC, COAD
CTA CEP55, KIF2C, TTK, OIP5, CASC5, NUF2, MAGEA, MAGEB, MAGEC, PAGE, NY-ESO-1, PRAME RGS22, TDRD6, TMEM108 COAD, UVM, THCA, UCEC BRCA, LUAD, BLCA, HNSC, THYM, LIHC, LAML, ACC, SARC, SKCM, CESC, LGG, LUSC
HLA HLA-J, DOA, DOB, DPB1, DQA1, DQB2 NA LIHC, HNSC, ACC, PRAD, LUAD CESC, COAD, LGG, SKCM
CCR TNFAIP8L3, CCL14, CX3CR1, CCL21, IL1R1, IL33, CCL19, CCR6, IL16, IL17D, TGFB2, TGFBR2, BMP3, CXCL12, TNFSF8 ILF2, CXCL9, CXCL10, CXCL11, ILKAP, IFNG LUSC, DLBC, UVM, TGCT, PRAD, LUAD, KIRC, ACC, HNSC, THCA, STAD, LIHC THYM
pro-inflammatory IL12A, IL12B, PRF1, TBX21 CXCL9, CXCL10, IFNG, GZMB, CXCL13, STAT1, IRF1, GNLY KIRC, TGCT, ACC, HNSC, KIRP, THCA CESC, COAD, UCEC, BLCA, LUAD, BRCA, STAD, LGG, SKCM, SARC
  1. aGenes with higher expression levels in the lower-TMB subtype than in the higher-TMB subtype of multiple cancer types (only some representative genes are listed)
  2. bGenes with higher expression levels in the higher-TMB subtype than in the lower-TMB subtype of multiple cancer types (only some representative genes are listed)