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Table 2 Subnormal serum IgG subclass levels in 219 adults with IgG subclass deficiency

From: Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

Subnormal IgG subclass immunophenotypesa Mannose-binding lectin ≤50 ng/mL
(n = 36)
Mannose-binding lectin > 50 ng/mL
(n = 183)
Value of p2
IgG1 alone, % (n) 38.9 (14) 29.5 (54) 0.3245
IgG2 alone, % (n) 0 0.55 (1) 1.0000
IgG3 alone, % (n) 25.0 (9) 29.0 (53) 0.6906
IgG1/IgG3, % (n) 22.2 (8) 25.7 (47) 0.8338
IgG1/IgG4, % (n) 0 3.3 (6) 0.5925
IgG2/IgG3, % (n) 8.3 (3) 1.1 (2) 0.0324
IgG3/IgG4, % (n) 0 2.2 (4) 1.0000
IgG1/IgG2/IgG3, % (n) 2.8 (1) 6.6 (12) 0.6992
IgG1/IgG3/IgG4, % (n) 2.8 (1) 1.6 (3) 0.5151
IgG2/IgG3/IgG4, % (n) 0 0.55 (1) 1.0000
  1. aSubnormal IgG subclass levels were defined as those > 2 standard deviations below the respective means: IgG1 < 4.2 g/L (< 422 mg/dL); IgG2 < 1.2 g/L (< 117 mg/dL); IgG3 < 0.4 g/L (< 41 mg/dL); and IgG4 0 g/L (< 1 mg/dL) [15]
  2. 2Comparisons were made with Fisher’s exact test (two-tailed). These are nominal values of p. Bonferroni correction for 10 comparisons yielded a revised p for significance of < 0.0050