Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

BMC Immunology

Table 2 Subnormal serum IgG subclass levels in 219 adults with IgG subclass deficiency

Subnormal IgG subclass immunophenotypes^a	Mannose-binding lectin ≤50 ng/mL (n = 36)	Mannose-binding lectin > 50 ng/mL (n = 183)	Value of p²
IgG1 alone, % (n)	38.9 (14)	29.5 (54)	0.3245
IgG2 alone, % (n)	0	0.55 (1)	1.0000
IgG3 alone, % (n)	25.0 (9)	29.0 (53)	0.6906
IgG1/IgG3, % (n)	22.2 (8)	25.7 (47)	0.8338
IgG1/IgG4, % (n)	0	3.3 (6)	0.5925
IgG2/IgG3, % (n)	8.3 (3)	1.1 (2)	0.0324
IgG3/IgG4, % (n)	0	2.2 (4)	1.0000
IgG1/IgG2/IgG3, % (n)	2.8 (1)	6.6 (12)	0.6992
IgG1/IgG3/IgG4, % (n)	2.8 (1)	1.6 (3)	0.5151
IgG2/IgG3/IgG4, % (n)	0	0.55 (1)	1.0000

^aSubnormal IgG subclass levels were defined as those > 2 standard deviations below the respective means: IgG1 < 4.2 g/L (< 422 mg/dL); IgG2 < 1.2 g/L (< 117 mg/dL); IgG3 < 0.4 g/L (< 41 mg/dL); and IgG4 0 g/L (< 1 mg/dL) [15]
²Comparisons were made with Fisher’s exact test (two-tailed). These are nominal values of p. Bonferroni correction for 10 comparisons yielded a revised p for significance of < 0.0050

ISSN: 1471-2172