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Table 3 Liver proteins with weak DS-affinity

From: A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

a    ANA (antinuclear autoantigens) Ref.
19 IPI00122011.2 Sf3b3 Isoform 1 of Splicing factor 3B subunit [63]
14 IPI00420807.3 Sfrs1 Isoform 1 of Splicing factor, arginine/serine-rich  
2 IPI00153743.1 Sfrs7 Isoform 2 of Splicing factor, arginine/serine-rich  
4 IPI00123604.4 Rpsa 40S ribosomal protein SA  
3 IPI00469260.3 Eftud2 116 kDa U5 small nuclear ribonucleoprotein component [64]
2 IPI00170008.1 Snrpa1 U2 small nuclear ribonucleoprotein A [65]
2 IPI00114052.1 Snrpb Small nuclear ribonucleoprotein-associated protein [13]
2 IPI00119220.1 Snrpd2 Small nuclear ribonucleoprotein Sm D2 [66]
2 IPI00226073.2 Hnrnpf Isoform 1 of Heterogeneous nuclear ribonucleoprotein F  
2 IPI00109860.3 Rbm8a Isoform 2 of RNA-binding protein 8  
    SMA (anti-smooth muscle autoantigens)/Cytoskeleton  
19 IPI00123316.1 Tpm1 Isoform 1 of Tropomyosin alpha-1 chain [67]
13 IPI00169707.2 Tpm3 Tropomyosin 3, gamm [68]
9 IPI00230044.5 Tpm3 Isoform 2 of Tropomyosin alpha-3 chain  
2 IPI00421223.3 Tpm4 Tropomyosin alpha-4 chain [69]
13 IPI00118899.1 Actn4 Alpha-actinin [70]
9 IPI00113539.2 Fn1 Fibronectin [71]
7 IPI00110850.1 Actb Actin, cytoplasmic [72]
6 IPI00110827.1 Acta1 Actin, alpha skeletal muscle [72]
7 IPI00265380.4 Myh8 Myosin-8 [73]
3 IPI00129404.1 Myh6 Myosin-6  
3 IPI00114894.1 Myh11 Isoform 1 of Myosin-1  
5 IPI00230394.5 Lmnb1 Lamin-B [74]
4 IPI00121892.9 Spnb2 Isoform 2 of Spectrin beta chain [75]
3 IPI00227299.6 Vim Vimentin [69]
2 IPI00109061.1 Tubb2b Tubulin beta-2B chain [76]
    AMA (anti-mitochondrial autoantigens)  
52 IPI00129526.1 Hsp90b1 Endoplasmin [26]
9 IPI00229080.7 Hsp90ab1 MCG1823  
4 IPI00330804.4 Hsp90aa1 Heat shock protein HSP 90-alpha  
39 IPI00136213.5 Sardh Sarcosine dehydrogenase, mitochondrial  
31 IPI00468481.2 Atp5b ATP synthase subunit beta, mitochondrial [77]
21 IPI00130280.1 Atp5a1 ATP synthase subunit alpha, mitochondrial  
27 IPI00471246.2 Ivd Isovaleryl-CoA dehydrogenase, mitochondrial  
17 IPI00134809.2 Dlst Isoform 1 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [78]
2 IPI00756386.1 Dhtkd1 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial  
13 IPI00331564.2 Dld Dihydrolipoyl dehydrogenase  
7 IPI00130535.1 Dbt Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [78]
3 IPI00153660.4 Dlat Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial  
13 IPI00387491.1 Aass Alpha-aminoadipic semialdehyde synthase, mitochondrial  
13 IPI00468653.4 Pccb Propionyl-CoA carboxylase beta chain, mitochondrial  
12 IPI00330523.1 Pcca Propionyl-CoA carboxylase alpha chain, mitochondrial  
11 IPI00110843.3 Agmat Agmatinase, mitochondrial  
9 IPI00114710.2 Pcx Pyruvate carboxylase, mitochondrial isoform 2  
7 IPI00111218.1 Aldh2 Aldehyde dehydrogenase, mitochondrial [27]
4 IPI00226430.2 Acaa2 3-Ketoacyl-CoA thiolase, mitochondrial  
3 IPI00119766.1 Rdh16 Retinol dehydrogenase 1  
3 IPI00405699.2 Aldh4a1 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial  
3 IPI00121309.2 Ndufs3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial  
3 IPI00753303.2 Npl22 Dihydrodipicolinate synthase-like, mitochondrial  
3 IPI00169862.1 Coq9 Ubiquinone biosynthesis protein COQ9, mitochondrial  
2 IPI00323592.2 Mdh2 Malate dehydrogenase, mitochondrial  
2 IPI00121105.2 Hadh Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial  
2 IPI00459725.2 Idh3a Isoform 1 of Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [79]
2 IPI00133553.1 Mut Methylmalonyl-CoA mutase, mitochondrial  
2 IPI00115607.3 Hadhb Trifunctional enzyme subunit beta, mitochondrial  
2 IPI00130804.1 Ech1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial [80]
2 IPI00469195.2 Echdc2 Isoform 1 of Enoyl-CoA hydratase domain-containing protein 2, mitochondrial  
2 IPI00314909.2 Agxt Alanine-glyoxylate aminotransferase  
2 IPI00226140.5 Maob Amine oxidase [flavin-containing] [81]
2 IPI00121440.4 Etfb Electron transfer flavoprotein subunit beta [82]
2 IPI00454008.1 Shmt2 Serine hydroxymethyltransferase  
    LKM (liver-kidney microsomal autoantigens)  
54 IPI00309073.2 Mttp Microsomal triglyceride transfer protein  
33 IPI00153317.3 Aldh1l1 10-formyltetrahydrofolate dehydrogenase  
10 IPI00111936.1 Ugt1a9 UDP-glucuronosyltransferase 1-9 [31]
8 IPI00762897.2 Ugcgl1 UDP-glucose:glycoprotein glucosyltransferase  
3 IPI00127223.3 Ugt2b36 UDP-glucuronosyltransferase  
3 IPI00114778.1 Cyp2c37 Cytochrome P450 2C37 [83]
3 IPI00131176.1 mt-Co2 Cytochrome c oxidase subunit 2  
2 IPI00323908.1 Cyp2d10 Cytochrome P450 2D10 [83]
3 IPI00331322.3 Mgst1 Microsomal glutathione S-transferase  
9 IPI00115867.4 Ces1 Liver carboxylesterase [35]
    Peroxisomal proteins  
6 IPI00331596.6 Pecr Peroxisomal trans-2-enoyl-CoA reductase  
3 IPI00134870.3 Acox2 Peroxisomal acyl-coenzyme A oxidase  
5 IPI00110719.1 Pipox Peroxisomal sarcosine oxidase [84]
2 IPI00130924.1 Slc27a2 Very long-chain acyl-CoA synthetaselow-den  
2 IPI00121833.3 Acaa1a Acaa1b 3-ketoacyl-CoA thiolase A, peroxisomal  
2 IPI00111235.2 Aldh3a2 Fatty aldehyde dehydrogenase variant  
    Apoptosis  
9 IPI00310240.4 Anxa6 Annexin A6 isoform [85]
5 IPI00116498.1 Ywhaz 14-3-3 protein zeta/delta [86]
5 IPI00118384.1 Ywhae 14-3-3 protein epsilon [87]
5 IPI00230707.6 Ywhag 14-3-3 protein gamma [87]
    Proteasome  
8 IPI00113845.1 Psmb1 Proteasome subunit beta type-1 [88]
4 IPI00119239.2 Psmb6 Proteasome subunit beta type-6  
3 IPI00116712.1 Psmb8 Proteasome subunit beta type-8  
2 IPI00128945.1 Psmb2 Proteasome subunit beta type-2  
2 IPI00129512.3 Psmb4 Proteasome subunit beta type-4  
2 IPI00136483.1 Psmb7 Proteasome subunit beta type-7  
5 IPI00331644.5 Psma3 Proteasome subunit alpha type-3 [88]
4 IPI00109122.1 Psma8 Proteasome subunit alpha type-7-like  
4 IPI00131845.1 Psma6 Proteasome subunit alpha type-6  
4 IPI00420745.7 Psma2 Proteasome subunit alpha type-2  
4 IPI00277001.4 Psma4 Proteasome subunit alpha type-4 [89]
    Miscellaneous  
68 IPI00123639.1 Calr Calreticulin [77]
67 IPI00271951.5 Pdia4 Protein disulfide isomerase A  
61 IPI00122815.3 P4hb Protein disulfide-isomerase [90]
17 IPI00222496.3 Pdia6 Putative uncharacterized protein  
2 IPI00163011.2 Txndc5 Thioredoxin domain-containing protein  
20 IPI00119618.1 Canx Calnexin [91]
18 IPI00622235.5 Vcp Transitional endoplasmic reticulum ATPase [92]
14 IPI00125514.1 Entpd5 Ectonucleoside triphosphate diphosphohydrolase 5  
11 IPI00475154.1 Rpn2 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit  
2 IPI00309035.2 Rpn1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit  
11 IPI00112719.1 Alad Delta-aminolevulinic acid dehydratase  
10 IPI00115680.1 Prkcsh Isoform 1 of Glucosidase 2 subunit beta  
7 IPI00119063.2 Lrp1 Pro-low-density lipoprotein receptor-related protein (alpha-2-macroglobulin receptor, apolipoprotein E receptor)  
2 IPI00624663.3 Pzp Alpha-2-macroglobulin  
7 IPI00135512.1 Cnpy2 Protein canopy homolog 2  
6 IPI00316314.1 Hacl1 2-hydroxyacyl-CoA lyase  
6 IPI00116254.1 Prdx4 Peroxiredoxin-4 [93]
6 IPI00125899.1 Ctnnb1 Catenin beta-1  
4 IPI00112963.1 Ctnna1 Catenin alpha-1 [94]
5 IPI00113869.1 Bsg Isoform 2 of Basigin (M6, EMMPRIN, TCSF, CD147)  
4 IPI00126184.7 Gc Vitamin D-binding protein [95]
4 IPI00123342.4 Hyou1 Hypoxia up-regulated protein  
3 IPI00130950.1 Bhmt Betaine--homocysteine S-methyltransferase [96]
3 IPI00134058.3 Erp44 Endoplasmic reticulum resident protein ERp44  
3 IPI00387282.4 Aadac Arylacetamide deacetylase  
3 IPI00122346.2 Ssr4 Signal sequence receptor, delta  
3 IPI00317740.5 Gnb2l1 Guanine nucleotide-binding protein subunit beta-2-like  
3 IPI00319973.3 Pgrmc1 Membrane-associated progesterone receptor component  
2 IPI00279218.1 Apeh Isoform 2 of Acylamino-acid-releasing enzyme  
2 IPI00323624.3 C3 Isoform Long of Complement C3 [97]
2 IPI00116432.1 Fmo1 Dimethylaniline monooxygenase [N-oxide-forming]  
2 IPI00114044.1 Man2a1 Alpha-mannosidase  
2 IPI00312018.6 Mlec Malectin  
2 IPI00115241.1 Mup4 Major urinary protein 4  
  1. aColumns left to right: Number of peptides identified for the protein by mass spectrometry; Protein ID; Gene name; Protein name; Reference (if any) reporting autoantibodies induced by the protein