a | Â | Â | ANA (antinuclear autoantigens) | Ref. |
---|---|---|---|---|
19 | IPI00122011.2 | Sf3b3 | Isoform 1 of Splicing factor 3B subunit | [63] |
14 | IPI00420807.3 | Sfrs1 | Isoform 1 of Splicing factor, arginine/serine-rich | Â |
2 | IPI00153743.1 | Sfrs7 | Isoform 2 of Splicing factor, arginine/serine-rich | Â |
4 | IPI00123604.4 | Rpsa | 40S ribosomal protein SA | Â |
3 | IPI00469260.3 | Eftud2 | 116 kDa U5 small nuclear ribonucleoprotein component | [64] |
2 | IPI00170008.1 | Snrpa1 | U2 small nuclear ribonucleoprotein A | [65] |
2 | IPI00114052.1 | Snrpb | Small nuclear ribonucleoprotein-associated protein | [13] |
2 | IPI00119220.1 | Snrpd2 | Small nuclear ribonucleoprotein Sm D2 | [66] |
2 | IPI00226073.2 | Hnrnpf | Isoform 1 of Heterogeneous nuclear ribonucleoprotein F | Â |
2 | IPI00109860.3 | Rbm8a | Isoform 2 of RNA-binding protein 8 | Â |
 |  |  | SMA (anti-smooth muscle autoantigens)/Cytoskeleton |  |
19 | IPI00123316.1 | Tpm1 | Isoform 1 of Tropomyosin alpha-1 chain | [67] |
13 | IPI00169707.2 | Tpm3 | Tropomyosin 3, gamm | [68] |
9 | IPI00230044.5 | Tpm3 | Isoform 2 of Tropomyosin alpha-3 chain | Â |
2 | IPI00421223.3 | Tpm4 | Tropomyosin alpha-4 chain | [69] |
13 | IPI00118899.1 | Actn4 | Alpha-actinin | [70] |
9 | IPI00113539.2 | Fn1 | Fibronectin | [71] |
7 | IPI00110850.1 | Actb | Actin, cytoplasmic | [72] |
6 | IPI00110827.1 | Acta1 | Actin, alpha skeletal muscle | [72] |
7 | IPI00265380.4 | Myh8 | Myosin-8 | [73] |
3 | IPI00129404.1 | Myh6 | Myosin-6 | Â |
3 | IPI00114894.1 | Myh11 | Isoform 1 of Myosin-1 | Â |
5 | IPI00230394.5 | Lmnb1 | Lamin-B | [74] |
4 | IPI00121892.9 | Spnb2 | Isoform 2 of Spectrin beta chain | [75] |
3 | IPI00227299.6 | Vim | Vimentin | [69] |
2 | IPI00109061.1 | Tubb2b | Tubulin beta-2B chain | [76] |
 |  |  | AMA (anti-mitochondrial autoantigens) |  |
52 | IPI00129526.1 | Hsp90b1 | Endoplasmin | [26] |
9 | IPI00229080.7 | Hsp90ab1 | MCG1823 | Â |
4 | IPI00330804.4 | Hsp90aa1 | Heat shock protein HSP 90-alpha | Â |
39 | IPI00136213.5 | Sardh | Sarcosine dehydrogenase, mitochondrial | Â |
31 | IPI00468481.2 | Atp5b | ATP synthase subunit beta, mitochondrial | [77] |
21 | IPI00130280.1 | Atp5a1 | ATP synthase subunit alpha, mitochondrial | Â |
27 | IPI00471246.2 | Ivd | Isovaleryl-CoA dehydrogenase, mitochondrial | Â |
17 | IPI00134809.2 | Dlst | Isoform 1 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | [78] |
2 | IPI00756386.1 | Dhtkd1 | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial | Â |
13 | IPI00331564.2 | Dld | Dihydrolipoyl dehydrogenase | Â |
7 | IPI00130535.1 | Dbt | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | [78] |
3 | IPI00153660.4 | Dlat | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | Â |
13 | IPI00387491.1 | Aass | Alpha-aminoadipic semialdehyde synthase, mitochondrial | Â |
13 | IPI00468653.4 | Pccb | Propionyl-CoA carboxylase beta chain, mitochondrial | Â |
12 | IPI00330523.1 | Pcca | Propionyl-CoA carboxylase alpha chain, mitochondrial | Â |
11 | IPI00110843.3 | Agmat | Agmatinase, mitochondrial | Â |
9 | IPI00114710.2 | Pcx | Pyruvate carboxylase, mitochondrial isoform 2 | Â |
7 | IPI00111218.1 | Aldh2 | Aldehyde dehydrogenase, mitochondrial | [27] |
4 | IPI00226430.2 | Acaa2 | 3-Ketoacyl-CoA thiolase, mitochondrial | Â |
3 | IPI00119766.1 | Rdh16 | Retinol dehydrogenase 1 | Â |
3 | IPI00405699.2 | Aldh4a1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Â |
3 | IPI00121309.2 | Ndufs3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | Â |
3 | IPI00753303.2 | Npl22 | Dihydrodipicolinate synthase-like, mitochondrial | Â |
3 | IPI00169862.1 | Coq9 | Ubiquinone biosynthesis protein COQ9, mitochondrial | Â |
2 | IPI00323592.2 | Mdh2 | Malate dehydrogenase, mitochondrial | Â |
2 | IPI00121105.2 | Hadh | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | Â |
2 | IPI00459725.2 | Idh3a | Isoform 1 of Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | [79] |
2 | IPI00133553.1 | Mut | Methylmalonyl-CoA mutase, mitochondrial | Â |
2 | IPI00115607.3 | Hadhb | Trifunctional enzyme subunit beta, mitochondrial | Â |
2 | IPI00130804.1 | Ech1 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial | [80] |
2 | IPI00469195.2 | Echdc2 | Isoform 1 of Enoyl-CoA hydratase domain-containing protein 2, mitochondrial | Â |
2 | IPI00314909.2 | Agxt | Alanine-glyoxylate aminotransferase | Â |
2 | IPI00226140.5 | Maob | Amine oxidase [flavin-containing] | [81] |
2 | IPI00121440.4 | Etfb | Electron transfer flavoprotein subunit beta | [82] |
2 | IPI00454008.1 | Shmt2 | Serine hydroxymethyltransferase | Â |
 |  |  | LKM (liver-kidney microsomal autoantigens) |  |
54 | IPI00309073.2 | Mttp | Microsomal triglyceride transfer protein | Â |
33 | IPI00153317.3 | Aldh1l1 | 10-formyltetrahydrofolate dehydrogenase | Â |
10 | IPI00111936.1 | Ugt1a9 | UDP-glucuronosyltransferase 1-9 | [31] |
8 | IPI00762897.2 | Ugcgl1 | UDP-glucose:glycoprotein glucosyltransferase | Â |
3 | IPI00127223.3 | Ugt2b36 | UDP-glucuronosyltransferase | Â |
3 | IPI00114778.1 | Cyp2c37 | Cytochrome P450 2C37 | [83] |
3 | IPI00131176.1 | mt-Co2 | Cytochrome c oxidase subunit 2 | Â |
2 | IPI00323908.1 | Cyp2d10 | Cytochrome P450 2D10 | [83] |
3 | IPI00331322.3 | Mgst1 | Microsomal glutathione S-transferase | Â |
9 | IPI00115867.4 | Ces1 | Liver carboxylesterase | [35] |
 |  |  | Peroxisomal proteins |  |
6 | IPI00331596.6 | Pecr | Peroxisomal trans-2-enoyl-CoA reductase | Â |
3 | IPI00134870.3 | Acox2 | Peroxisomal acyl-coenzyme A oxidase | Â |
5 | IPI00110719.1 | Pipox | Peroxisomal sarcosine oxidase | [84] |
2 | IPI00130924.1 | Slc27a2 | Very long-chain acyl-CoA synthetaselow-den | Â |
2 | IPI00121833.3 | Acaa1a | Acaa1b 3-ketoacyl-CoA thiolase A, peroxisomal | Â |
2 | IPI00111235.2 | Aldh3a2 | Fatty aldehyde dehydrogenase variant | Â |
 |  |  | Apoptosis |  |
9 | IPI00310240.4 | Anxa6 | Annexin A6 isoform | [85] |
5 | IPI00116498.1 | Ywhaz | 14-3-3 protein zeta/delta | [86] |
5 | IPI00118384.1 | Ywhae | 14-3-3 protein epsilon | [87] |
5 | IPI00230707.6 | Ywhag | 14-3-3 protein gamma | [87] |
 |  |  | Proteasome |  |
8 | IPI00113845.1 | Psmb1 | Proteasome subunit beta type-1 | [88] |
4 | IPI00119239.2 | Psmb6 | Proteasome subunit beta type-6 | Â |
3 | IPI00116712.1 | Psmb8 | Proteasome subunit beta type-8 | Â |
2 | IPI00128945.1 | Psmb2 | Proteasome subunit beta type-2 | Â |
2 | IPI00129512.3 | Psmb4 | Proteasome subunit beta type-4 | Â |
2 | IPI00136483.1 | Psmb7 | Proteasome subunit beta type-7 | Â |
5 | IPI00331644.5 | Psma3 | Proteasome subunit alpha type-3 | [88] |
4 | IPI00109122.1 | Psma8 | Proteasome subunit alpha type-7-like | Â |
4 | IPI00131845.1 | Psma6 | Proteasome subunit alpha type-6 | Â |
4 | IPI00420745.7 | Psma2 | Proteasome subunit alpha type-2 | Â |
4 | IPI00277001.4 | Psma4 | Proteasome subunit alpha type-4 | [89] |
 |  |  | Miscellaneous |  |
68 | IPI00123639.1 | Calr | Calreticulin | [77] |
67 | IPI00271951.5 | Pdia4 | Protein disulfide isomerase A | Â |
61 | IPI00122815.3 | P4hb | Protein disulfide-isomerase | [90] |
17 | IPI00222496.3 | Pdia6 | Putative uncharacterized protein | Â |
2 | IPI00163011.2 | Txndc5 | Thioredoxin domain-containing protein | Â |
20 | IPI00119618.1 | Canx | Calnexin | [91] |
18 | IPI00622235.5 | Vcp | Transitional endoplasmic reticulum ATPase | [92] |
14 | IPI00125514.1 | Entpd5 | Ectonucleoside triphosphate diphosphohydrolase 5 | Â |
11 | IPI00475154.1 | Rpn2 | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit | Â |
2 | IPI00309035.2 | Rpn1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit | Â |
11 | IPI00112719.1 | Alad | Delta-aminolevulinic acid dehydratase | Â |
10 | IPI00115680.1 | Prkcsh | Isoform 1 of Glucosidase 2 subunit beta | Â |
7 | IPI00119063.2 | Lrp1 | Pro-low-density lipoprotein receptor-related protein (alpha-2-macroglobulin receptor, apolipoprotein E receptor) | Â |
2 | IPI00624663.3 | Pzp | Alpha-2-macroglobulin | Â |
7 | IPI00135512.1 | Cnpy2 | Protein canopy homolog 2 | Â |
6 | IPI00316314.1 | Hacl1 | 2-hydroxyacyl-CoA lyase | Â |
6 | IPI00116254.1 | Prdx4 | Peroxiredoxin-4 | [93] |
6 | IPI00125899.1 | Ctnnb1 | Catenin beta-1 | Â |
4 | IPI00112963.1 | Ctnna1 | Catenin alpha-1 | [94] |
5 | IPI00113869.1 | Bsg | Isoform 2 of Basigin (M6, EMMPRIN, TCSF, CD147) | Â |
4 | IPI00126184.7 | Gc | Vitamin D-binding protein | [95] |
4 | IPI00123342.4 | Hyou1 | Hypoxia up-regulated protein | Â |
3 | IPI00130950.1 | Bhmt | Betaine--homocysteine S-methyltransferase | [96] |
3 | IPI00134058.3 | Erp44 | Endoplasmic reticulum resident protein ERp44 | Â |
3 | IPI00387282.4 | Aadac | Arylacetamide deacetylase | Â |
3 | IPI00122346.2 | Ssr4 | Signal sequence receptor, delta | Â |
3 | IPI00317740.5 | Gnb2l1 | Guanine nucleotide-binding protein subunit beta-2-like | Â |
3 | IPI00319973.3 | Pgrmc1 | Membrane-associated progesterone receptor component | Â |
2 | IPI00279218.1 | Apeh | Isoform 2 of Acylamino-acid-releasing enzyme | Â |
2 | IPI00323624.3 | C3 | Isoform Long of Complement C3 | [97] |
2 | IPI00116432.1 | Fmo1 | Dimethylaniline monooxygenase [N-oxide-forming] | Â |
2 | IPI00114044.1 | Man2a1 | Alpha-mannosidase | Â |
2 | IPI00312018.6 | Mlec | Malectin | Â |
2 | IPI00115241.1 | Mup4 | Major urinary protein 4 | Â |