Skip to main content

Table 3 Liver proteins with weak DS-affinity

From: A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

a

  

ANA (antinuclear autoantigens)

Ref.

19

IPI00122011.2

Sf3b3

Isoform 1 of Splicing factor 3B subunit

[63]

14

IPI00420807.3

Sfrs1

Isoform 1 of Splicing factor, arginine/serine-rich

 

2

IPI00153743.1

Sfrs7

Isoform 2 of Splicing factor, arginine/serine-rich

 

4

IPI00123604.4

Rpsa

40S ribosomal protein SA

 

3

IPI00469260.3

Eftud2

116 kDa U5 small nuclear ribonucleoprotein component

[64]

2

IPI00170008.1

Snrpa1

U2 small nuclear ribonucleoprotein A

[65]

2

IPI00114052.1

Snrpb

Small nuclear ribonucleoprotein-associated protein

[13]

2

IPI00119220.1

Snrpd2

Small nuclear ribonucleoprotein Sm D2

[66]

2

IPI00226073.2

Hnrnpf

Isoform 1 of Heterogeneous nuclear ribonucleoprotein F

 

2

IPI00109860.3

Rbm8a

Isoform 2 of RNA-binding protein 8

 
   

SMA (anti-smooth muscle autoantigens)/Cytoskeleton

 

19

IPI00123316.1

Tpm1

Isoform 1 of Tropomyosin alpha-1 chain

[67]

13

IPI00169707.2

Tpm3

Tropomyosin 3, gamm

[68]

9

IPI00230044.5

Tpm3

Isoform 2 of Tropomyosin alpha-3 chain

 

2

IPI00421223.3

Tpm4

Tropomyosin alpha-4 chain

[69]

13

IPI00118899.1

Actn4

Alpha-actinin

[70]

9

IPI00113539.2

Fn1

Fibronectin

[71]

7

IPI00110850.1

Actb

Actin, cytoplasmic

[72]

6

IPI00110827.1

Acta1

Actin, alpha skeletal muscle

[72]

7

IPI00265380.4

Myh8

Myosin-8

[73]

3

IPI00129404.1

Myh6

Myosin-6

 

3

IPI00114894.1

Myh11

Isoform 1 of Myosin-1

 

5

IPI00230394.5

Lmnb1

Lamin-B

[74]

4

IPI00121892.9

Spnb2

Isoform 2 of Spectrin beta chain

[75]

3

IPI00227299.6

Vim

Vimentin

[69]

2

IPI00109061.1

Tubb2b

Tubulin beta-2B chain

[76]

   

AMA (anti-mitochondrial autoantigens)

 

52

IPI00129526.1

Hsp90b1

Endoplasmin

[26]

9

IPI00229080.7

Hsp90ab1

MCG1823

 

4

IPI00330804.4

Hsp90aa1

Heat shock protein HSP 90-alpha

 

39

IPI00136213.5

Sardh

Sarcosine dehydrogenase, mitochondrial

 

31

IPI00468481.2

Atp5b

ATP synthase subunit beta, mitochondrial

[77]

21

IPI00130280.1

Atp5a1

ATP synthase subunit alpha, mitochondrial

 

27

IPI00471246.2

Ivd

Isovaleryl-CoA dehydrogenase, mitochondrial

 

17

IPI00134809.2

Dlst

Isoform 1 of Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

[78]

2

IPI00756386.1

Dhtkd1

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

 

13

IPI00331564.2

Dld

Dihydrolipoyl dehydrogenase

 

7

IPI00130535.1

Dbt

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

[78]

3

IPI00153660.4

Dlat

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

 

13

IPI00387491.1

Aass

Alpha-aminoadipic semialdehyde synthase, mitochondrial

 

13

IPI00468653.4

Pccb

Propionyl-CoA carboxylase beta chain, mitochondrial

 

12

IPI00330523.1

Pcca

Propionyl-CoA carboxylase alpha chain, mitochondrial

 

11

IPI00110843.3

Agmat

Agmatinase, mitochondrial

 

9

IPI00114710.2

Pcx

Pyruvate carboxylase, mitochondrial isoform 2

 

7

IPI00111218.1

Aldh2

Aldehyde dehydrogenase, mitochondrial

[27]

4

IPI00226430.2

Acaa2

3-Ketoacyl-CoA thiolase, mitochondrial

 

3

IPI00119766.1

Rdh16

Retinol dehydrogenase 1

 

3

IPI00405699.2

Aldh4a1

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

 

3

IPI00121309.2

Ndufs3

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

 

3

IPI00753303.2

Npl22

Dihydrodipicolinate synthase-like, mitochondrial

 

3

IPI00169862.1

Coq9

Ubiquinone biosynthesis protein COQ9, mitochondrial

 

2

IPI00323592.2

Mdh2

Malate dehydrogenase, mitochondrial

 

2

IPI00121105.2

Hadh

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

 

2

IPI00459725.2

Idh3a

Isoform 1 of Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

[79]

2

IPI00133553.1

Mut

Methylmalonyl-CoA mutase, mitochondrial

 

2

IPI00115607.3

Hadhb

Trifunctional enzyme subunit beta, mitochondrial

 

2

IPI00130804.1

Ech1

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

[80]

2

IPI00469195.2

Echdc2

Isoform 1 of Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

 

2

IPI00314909.2

Agxt

Alanine-glyoxylate aminotransferase

 

2

IPI00226140.5

Maob

Amine oxidase [flavin-containing]

[81]

2

IPI00121440.4

Etfb

Electron transfer flavoprotein subunit beta

[82]

2

IPI00454008.1

Shmt2

Serine hydroxymethyltransferase

 
   

LKM (liver-kidney microsomal autoantigens)

 

54

IPI00309073.2

Mttp

Microsomal triglyceride transfer protein

 

33

IPI00153317.3

Aldh1l1

10-formyltetrahydrofolate dehydrogenase

 

10

IPI00111936.1

Ugt1a9

UDP-glucuronosyltransferase 1-9

[31]

8

IPI00762897.2

Ugcgl1

UDP-glucose:glycoprotein glucosyltransferase

 

3

IPI00127223.3

Ugt2b36

UDP-glucuronosyltransferase

 

3

IPI00114778.1

Cyp2c37

Cytochrome P450 2C37

[83]

3

IPI00131176.1

mt-Co2

Cytochrome c oxidase subunit 2

 

2

IPI00323908.1

Cyp2d10

Cytochrome P450 2D10

[83]

3

IPI00331322.3

Mgst1

Microsomal glutathione S-transferase

 

9

IPI00115867.4

Ces1

Liver carboxylesterase

[35]

   

Peroxisomal proteins

 

6

IPI00331596.6

Pecr

Peroxisomal trans-2-enoyl-CoA reductase

 

3

IPI00134870.3

Acox2

Peroxisomal acyl-coenzyme A oxidase

 

5

IPI00110719.1

Pipox

Peroxisomal sarcosine oxidase

[84]

2

IPI00130924.1

Slc27a2

Very long-chain acyl-CoA synthetaselow-den

 

2

IPI00121833.3

Acaa1a

Acaa1b 3-ketoacyl-CoA thiolase A, peroxisomal

 

2

IPI00111235.2

Aldh3a2

Fatty aldehyde dehydrogenase variant

 
   

Apoptosis

 

9

IPI00310240.4

Anxa6

Annexin A6 isoform

[85]

5

IPI00116498.1

Ywhaz

14-3-3 protein zeta/delta

[86]

5

IPI00118384.1

Ywhae

14-3-3 protein epsilon

[87]

5

IPI00230707.6

Ywhag

14-3-3 protein gamma

[87]

   

Proteasome

 

8

IPI00113845.1

Psmb1

Proteasome subunit beta type-1

[88]

4

IPI00119239.2

Psmb6

Proteasome subunit beta type-6

 

3

IPI00116712.1

Psmb8

Proteasome subunit beta type-8

 

2

IPI00128945.1

Psmb2

Proteasome subunit beta type-2

 

2

IPI00129512.3

Psmb4

Proteasome subunit beta type-4

 

2

IPI00136483.1

Psmb7

Proteasome subunit beta type-7

 

5

IPI00331644.5

Psma3

Proteasome subunit alpha type-3

[88]

4

IPI00109122.1

Psma8

Proteasome subunit alpha type-7-like

 

4

IPI00131845.1

Psma6

Proteasome subunit alpha type-6

 

4

IPI00420745.7

Psma2

Proteasome subunit alpha type-2

 

4

IPI00277001.4

Psma4

Proteasome subunit alpha type-4

[89]

   

Miscellaneous

 

68

IPI00123639.1

Calr

Calreticulin

[77]

67

IPI00271951.5

Pdia4

Protein disulfide isomerase A

 

61

IPI00122815.3

P4hb

Protein disulfide-isomerase

[90]

17

IPI00222496.3

Pdia6

Putative uncharacterized protein

 

2

IPI00163011.2

Txndc5

Thioredoxin domain-containing protein

 

20

IPI00119618.1

Canx

Calnexin

[91]

18

IPI00622235.5

Vcp

Transitional endoplasmic reticulum ATPase

[92]

14

IPI00125514.1

Entpd5

Ectonucleoside triphosphate diphosphohydrolase 5

 

11

IPI00475154.1

Rpn2

Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit

 

2

IPI00309035.2

Rpn1

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit

 

11

IPI00112719.1

Alad

Delta-aminolevulinic acid dehydratase

 

10

IPI00115680.1

Prkcsh

Isoform 1 of Glucosidase 2 subunit beta

 

7

IPI00119063.2

Lrp1

Pro-low-density lipoprotein receptor-related protein (alpha-2-macroglobulin receptor, apolipoprotein E receptor)

 

2

IPI00624663.3

Pzp

Alpha-2-macroglobulin

 

7

IPI00135512.1

Cnpy2

Protein canopy homolog 2

 

6

IPI00316314.1

Hacl1

2-hydroxyacyl-CoA lyase

 

6

IPI00116254.1

Prdx4

Peroxiredoxin-4

[93]

6

IPI00125899.1

Ctnnb1

Catenin beta-1

 

4

IPI00112963.1

Ctnna1

Catenin alpha-1

[94]

5

IPI00113869.1

Bsg

Isoform 2 of Basigin (M6, EMMPRIN, TCSF, CD147)

 

4

IPI00126184.7

Gc

Vitamin D-binding protein

[95]

4

IPI00123342.4

Hyou1

Hypoxia up-regulated protein

 

3

IPI00130950.1

Bhmt

Betaine--homocysteine S-methyltransferase

[96]

3

IPI00134058.3

Erp44

Endoplasmic reticulum resident protein ERp44

 

3

IPI00387282.4

Aadac

Arylacetamide deacetylase

 

3

IPI00122346.2

Ssr4

Signal sequence receptor, delta

 

3

IPI00317740.5

Gnb2l1

Guanine nucleotide-binding protein subunit beta-2-like

 

3

IPI00319973.3

Pgrmc1

Membrane-associated progesterone receptor component

 

2

IPI00279218.1

Apeh

Isoform 2 of Acylamino-acid-releasing enzyme

 

2

IPI00323624.3

C3

Isoform Long of Complement C3

[97]

2

IPI00116432.1

Fmo1

Dimethylaniline monooxygenase [N-oxide-forming]

 

2

IPI00114044.1

Man2a1

Alpha-mannosidase

 

2

IPI00312018.6

Mlec

Malectin

 

2

IPI00115241.1

Mup4

Major urinary protein 4

 
  1. aColumns left to right: Number of peptides identified for the protein by mass spectrometry; Protein ID; Gene name; Protein name; Reference (if any) reporting autoantibodies induced by the protein