Table 4 Geometric mean titres of levels of total IgG in day 70 sera to the homologous FVO AMA1 antigen and 3 heterologous (3D7, HB3, and CAMP) variants (N = 12) rabbits
From: Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits
Group | FVO | 3D7 | HB3 | CAMP |
|---|---|---|---|---|
Stable o/w Emulsion (SE) | 27769 (18492 to 41701) | 3624 (2230 to 5890) | 25493 (16707 to 38898) | 12243 (8530 to 17572) |
SE-Glucopyranosyl Lipid A (GLA) | 17526 (11819 to 25989) | 3130 (2114 to 4633) | 15695 (9761 to 25239) | 8239 (5288 to 12837) |
Liposomes | 2683 (1570 to 4586) | 805 (440 to 1473) | 2894 (1619 to 5175) | 1486 (822 to 2687) |
Liposomes-GLA | 3667 (2283 to 5892) | 859 (427 to 1725) | 4114 (2099 to 8064) | 1716 (942 to 3128) |
CoVaccine HT™ | 140707 (100939 to 196143) | 24151 (16906 to 34501) | 102988 (77022 to 137709) | 82696 (57257 to 119436) |
ImSaVac-P | 21088 (12988 to 34240) | 4574 (3166 to 6609) | 18190 (11392 to 29044) | 11197 (6908 to 18149) |
ImSaVac-P o/w | 6490 (2675 to 15749) | 1554 (678 to 3559) | 6961 (2714 to 17853) | 2814 (1109 to 7142) |