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Fig. 5 | BMC Immunology

Fig. 5

From: CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

Fig. 5

Effect of LAG-3 and PD-L1 blockade on Treg expansion and inhibitory cytokine secretion by CD4+ T cells. a. Foxp3 expression on CD25+ T cells after HBV antigen stimulation with anti-IgG1 (isotype), anti-LAG-3, anti-PD-1, and anti-LAG-3 with anti-PD-1 for 48 h. Graphs showing events after gating on CD3+CD4+ T cells. b IL-10 secretion from CD4+ T cells after incubation of antigens with anti-IgG1 (isotype), anti-LAG-3, anti-PD-1 and anti-LAG-3 together with anti-PD-1 for 48 h. **P < 0.01, ***P < 0.001

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BMC Immunology

ISSN: 1471-2172

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