Fig. 2

Therapeutic effect of Fc-μTP-L309C in experimental arthritis.The clinical scores (a) and paw width measurements (b) are shown for mice treated with multiple doses of 2 g/kg of SCIg or with multiple doses of 200 mg/kg, 100 mg/kg, or 50 mg/kg of Fc-μTP-L309C, using HSA-treated mice as a control. Injections were given on days 1, 3, 5, 7, 9, and 11. Shown are the average clinical scores and the average paw width measurements (mm); error bars indicate range of clinical scores/range of paw widths (mean ± SD; n = 5 for each treatment group). ***P < 0.0001 200 mg/kg Fc-μTP-L309C vs. 2000 mg/kg SCIg