Characteristics and reference ranges of CD4+T cell subpopulations among healthy adult Han Chinese in Shanxi Province, North China

Table 2 Distribution and reference ranges of CD4⁺T cell subpopulations based on age and sex

Parameters	Age (years)	Median		P-value	Reference ranges ^a)
Parameters	Age (years)	Male	Female	P-value	Male	Female
CD4⁺T subpopulations (%)
Th1	≤ 40	16.77	13.43	0.191	0.58–39.41	0.40–49.52
Th1	> 40	17.10	16.19	0.191	0.33–42.26	0.41–31.06
Th2	≤ 40	1.19	1.26	0.083	0.43–3.70	0.52–3.54
Th2	> 40	0.99	0.94	0.083	0.24–2.83	0.18–3.92
Th17	≤ 40	1.08	1.15	0.229	0.20–3.14	0.23–4.46
Th17	> 40	1.12	0.91	0.229	0.31–2.70	0.16–2.05
Treg	≤ 40	4.92	3.88	0.043 ^b)	2.06–8.26	2.02–7.93
Treg	> 40	5.14	4.74	0.043 ^b)	2.56–8.00	2.06–8.26
Th1:Th2	≤ 40	13.06	9.89	0.015 ^c)	0.51–77.00	0.53–40.91
Th1:Th2	> 40	17.43	14.39	0.015 ^c)	0.20–114.76	1.40–84.62
Th17:Treg	≤ 40	0.22	0.25	0.059	0.04–1.18	0.03–0.76
Th17:Treg	> 40	0.23	0.17	0.059	0.05–0.70	0.03–0.78
CD4⁺T subpopulations (cells/μl)
Th1	≤ 40	106.02	80.64	0.125	2.90–280.46	2.11–311.24
Th1	> 40	128.70	104.85	0.125	1.82–260.03	2.37–273.85
Th2	≤ 40	8.14	9.29	0.341	2.94–23.57	2.90–29.17
Th2	> 40	7.56	8.17	0.341	1.41–26.30	1.10–26.93
Th17	≤ 40	7.33	6.48	0.423	0.91–22.44	1.26–16.34
Th17	> 40	8.27	6.39	0.423	1.56–22.09	0.82–15.28
Treg	≤ 40	29.68	24.64	0.022 ^b)	13.54–62.54	11.76–50.83
Treg	> 40	36.20	31.20	0.022 ^b)	13.26–66.61	14.78–70.93

^a) Reference ranges are defined as 95% of the population
^b) Numbers of cell subtypes with significant differences among members of age- and sex-grouped populations
^c) ratio of cell subtypes with significant differences among members of age- and sex-grouped populations
Statistics: Kruskal-Wallis χ² test

ISSN: 1471-2172