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Fig. 3 | BMC Immunology

Fig. 3

From: Tertiary lymphoid structure related B-cell IgE isotype switching and secondary lymphoid organ linked IgE production in mouse allergy model

Fig. 3

Systematic and local anaphylactic response in BALB/c mice is associated mostly with specific IgE production. a: BALB/c mice (n = 6–7 per group) intact (0) or immunized with 100 or 10,000 ng/injection OVA in the withers 3 times a week for 4 weeks. A decrease in the temperature (−dT Co) was estimated after systematic allergen challenge 3 days after the last OVA immunization by injecting 200 ul of 0,25% OVA i.p. Significance *p < 0.05; **p < 0.01 between indicated groups. b: Representative images of Evans Blue local anaphylaxis assay in different immunization groups. Doses in μg of OVA injected are shown. Arrows show the sites of reactions. c-e: Correlation between specific IgE (c), IgG1 (d), total IgE (e) production and temperature decrease after systematic allergen challenge in low dose (100 ng) immunized mice (n = 14). f: Correlations between OVA-specific to total IgE ratio and temperature decrease. g: Correlations between specific IgG1 and specific IgE production. h: Correlations between specific and total IgE

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BMC Immunology

ISSN: 1471-2172

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