Fig. 1
A comparison of prednisolone- and dexamethasone-mediated reduction of type-2 cytokine mRNA levels in primary Th2 cells. Fold differences in mRNA level from corticosteroid (CS) treated cells compared to vehicle are provided (n = 3). Quantification of IL-13 mRNA following steroid treatment (a). Comparison of CS ability to suppress IL-13 (b). The half maximal inhibitory concentration (IC50) for prednisolone and dexamethasone required to suppress IL-13 mRNA expression (c). Quantification of IL-5 mRNA following CS treatment (d). Comparison of the ability of either CS to suppress IL-5 (e). A comparison of the IC50 values for prednisolone and dexamethasone required to suppress IL-5 mRNA expression (f). Cell counts following culture in vehicle or increasing concentration of prednisolone or dexamethasone (f). Data represent mean and standard error. Pred, prednisolone; Dex, dexamethasone.*p < 0.05 determined by one-way (a, d & g) or two-way (b & e) RM ANOVA or t-test (c & f)