Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

Kousha, Ahmad; Mahdavi Gorabi, Armita; Forouzesh, Mehdi; Hosseini, Mojgan; Alexander, Markov; Imani, Danyal; Razi, Bahman; Mousavi, Mohammad Javad; Aslani, Saeed; Mikaeili, Haleh

doi:10.1186/s12865-020-00384-7

Table 2 Distribution of genotype and allele among asthma patients and controls

From: Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

Study author	Asthma cases					Healthy control					P-HWE	MAF
Study author	CC	CT	TT	C	T	CC	CT	TT	C	T	P-HWE	MAF
Walley et al. [29]	56	55	13	167	81	31	23	5	85	33	0/8	0/72
Hijazi et al. [30]	5	25	54	35	133	9	31	60	49	151	0/1	0/245
Sandford et al. [31]	146	78	9	370	96	100	41	2	241	45	0/33	0/842
Takabayashi et al. [32]	6	43	51	55	145	10	39	51	59	141	0/53	0/295
Hakonarson et al. [33]	73	20	1	166	22	67	25	2	159	29	0/85	0/845
Cui et al. [34]	11	89	141	111	371	9	52	114	70	280	0/34	0/2
Basehore et al. (i) [16]	153	72	8	378	88	181	59	5	421	69	0/94	0/859
Basehore et al. (ii) [16]	22	77	69	121	215	29	119	121	177	361	0/97	0/329
Basehore et al. (iii) [16]	43	55	18	141	91	55	59	16	169	91	0/97	0/65
Lee et al. [35]	9	77	168	95	413	3	29	68	35	165	0/96	0/175
Park et al. [36]	19	164	349	202	862	7	54	109	68	272	0/92	0/2
Wang et al. [37]	29	42	22	100	86	21	26	15	68	56	0/22	0/548
Adjers et al. [38]	106	103	34	315	171	189	164	48	542	260	0/18	0/675
Donfack et al. (i) [26]	85	34	7	204	48	144	55	6	343	67	0/78	0/836
Donfack et al. (ii) [26]	25	82	98	132	278	24	82	77	130	236	0/76	0/355
Zhang et al. (i) [27]	4	47	101	55	249	3	45	109	51	263	0/5	0/162
Zhang et al. (ii) [27]	11	35	30	57	95	16	43	41	75	125	0/4	0/375
Zhang et al. (iii) [27]	50	31	6	131	43	66	30	7	162	44	0/17	0/786
Gervaziev et al. [39]	16	75	18	107	111	18	43	7	79	57	0/01	0/58
Schubert et al. [40]	143	78	10	364	98	189	74	7	452	88	0/93	0/837
Kabesch et al. [41]	42	29	2	113	33	564	188	21	1316	230	0/26	0/851
Battle et al. [42]	28	113	114	169	341	19	77	79	115	235	0/97	0/328
Hosseini-Farahabadi et al. [43]	17	8	5	42	18	38	12	0	88	12	0/33	0/88
Kamali-Sarvestani et al. [44]	139	6	4	284	14	93	18	1	204	20	0/9	0/91
Chiang et al. [45]	1	19	147	21	313	7	34	70	48	174	0/31	0/216
Mak et al. [46]	15	95	179	125	453	19	87	186	125	459	0/05	0/214
Attab et al. [47]	31	9	0	71	9	33	7	0	73	7	0/54	0/912
De Faria et al. [48]	38	41	9	117	59	67	108	27	242	162	0/1	0/599
Jiang et al. [49]	0	8	5	8	18	1	9	3	11	15	0/13	0/423
Amirzargar et al. [50]	0	59	0	59	59	10	129	0	149	129	< 0.001	0/535
Daley et al. [51]	476	155	13	1107	181	549	186	16	1284	218	0/95	0/854
Haller et al. [52]	6	30	36	42	102	7	31	32	45	95	0/89	0/321
Rad et al. [53]	46	18	0	110	18	42	23	0	107	23	0/08	0/823
Wu et al. [54]	6	83	163	95	409	11	84	132	106	348	0/61	0/233
Beghe et al. [55]	232	63	4	527	71	136	37	3	309	43	0/79	0/877
Bijanzadeh et al. [56]	92	4	4	188	12	48	1	1	97	3	< 0.001	0/97
Fance et al. [57]	38	13	11	89	35	27	1	2	55	5	< 0.001	0/916
Baye et al. (i) [28]	267	130	16	664	162	233	61	4	527	69	0/99	0/884
Baye et al. (ii) [28]	35	140	140	210	420	12	25	14	49	53	0/89	0/48
Daneshmandi et al. [58]	63	15	3	141	21	94	26	4	214	34	0/2	0/862
Huang et al. [59]	1	19	80	21	179	4	43	75	51	193	0/46	0/209
Hwang et al. [60]	1	51	136	53	323	12	89	275	113	639	0/15	0/15
Chiang et al. [61]	13	110	329	136	768	7	34	65	48	164	0/38	0/226
Micheal et al. [62]	26	63	19	115	101	31	84	5	146	94	< 0.001	0/608
Ricciardolo et al. [63]	35	19	3	89	25	109	12	3	230	18	< 0.001	0/927
Smolnikova et al. [64]	36	28	0	100	28	39	11	0	89	11	0/38	0/89
Li et al. [65]	17	150	324	184	798	21	144	338	186	820	0/26	0/184
Wang et al. [66]	50	177	165	277	507	104	412	333	620	1078	0/17	0/365
Dahmani et al. [67]	13	19	12	45	43	6	11	2	23	15	0/35	0/605
Li et al. [68]	112	0	205	224	410	138	0	213	276	426	< 0.001	0/393
Narozna et al. [69]	117	55	5	289	65	133	53	3	319	59	0/37	0/843
Zhang et al. [68]	8	11	19	27	49	17	13	5	47	23	0/34	0/671
Hussein et al. [70]	42	5	1	89	7	8	13	4	29	21	0/73	0/58
Abood et al. [71]	66	17	17	149	51	7	90	3	104	96	< 0.001	0/52
Zhang et al. [72]	7	13	17	27	47	11	15	3	37	21	0/51	0/637

P-HWE p-value for Hardy–Weinberg equilibrium, MAF minor allele frequency of control group

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