Table 3 Main results of pooled ORs in meta-analysis of IL-4 gene polymorphisms in asthmatic patients

Overall

Dominant model

9579 / 9881

1.22

1.04–1.44 (0.01)

69.7

< 0.001

- 1.33

0.24

- 1.17

0.39

Recessive model

9579 / 9881

1.17

1.08–1.27 (< 0.001)

48.5

< 0.001

−1.38

0.16

−0.60

0.55

Allelic model

9579 / 9881

1.21

1.09–1.33 (< 0.001)

71.1

< 0.001

− 1.05

0.41

−1.82

0.07

TT vs. CC

9579 / 9881

1.34

1.18–1.52 (< 0.001)

30.5

0.02

−1.25

0.24

−1.90

0.65

CT vs. CC

9579 / 9881

1.13

0.95–1.34 (0.17)

68.7

< 0.001

−2.06

0.33

−1.73

0.09

 Pediatrics

Dominant model

3061 / 3536

1.54

1.24–1.92 (< 0.001)

41

0.04

− 1.93

0.05

−1.63

0.23

Recessive model

3061 / 3536

1.20

1.05–1.37 (< 0.001)

58.3

< 0.001

−0.36

0.71

−1.14

0.27

Allelic model

3061 / 3536

1.37

1.16–1.63 (< 0.001)

68

< 0.001

−1.53

0.12

− 1.99

0.06

TT vs. CC

3061 / 3536

1.51

1.22–1.87 (< 0.001)

51.6

0.01

−1.44

0.15

−1.47

0.24

CT vs. CC

3061 / 3536

1.49

1.23–1.81 (< 0.001)

10.6

0.33

−1.92

0.05

−1.22

0.42

 Adults

Dominant model

2933 / 2670

1.23

1.01–1.51 (0.04)

35.2

0.066

−2.10

0.03

−1.86

0.08

Recessive model

2933 / 2670

1.21

1.04–1.40 (0.01)

46

0.01

−0.91

0.36

−0.71

0.48

Allelic model

2933 / 2670

1.24

1.05–1.47 (< 0.001)

63.8

< 0.001

−0.97

0.33

−1.45

0.16

TT vs. CC

2933 / 2670

1.37

1.09–1.72 (< 0.001)

5

0.39

−1.01

0.47

−1.77

0.19

CT vs. CC

2933 / 2670

1.15

0.96–1.39 (0.13)

23

0.17

−2.13

0.03

−1.56

0.13

 Mixed

Dominant model

3585 / 3675

0.92

0.65–1.32 (0.65)

83.6

< 0.001

−0.09

0.92

− 1.05

0.31

Recessive model

3585 / 3675

1.12

0.97–1.28 (0.11)

45.4

0.02

−0.41

0.68

0.39

0.70

Allelic model

3585 / 3675

1.03

0.85–1.24 (0.78)

76.3

< 0.001

−0.72

0.47

0.02

0.98

TT vs. CC

3585 / 3675

1.14

0.91–1.42 (0.24)

20.8

0.21

−0.18

0.85

−0.28

0.87

CT vs. CC

3585 / 3675

0.87

0.59–1.28 (0.48)

84.9

< 0.001

0

1

−1.11

0.28

 Asia

Dominant model

5196 / 4936

1.15

0.84–1.56 (0.39)

75.6

< 0.001

−1.86

0.06

−1.44

0.20

Recessive model

5196 / 4936

1.16

1.06–1.28 (< 0.001)

65

< 0.001

−1.62

0.10

−0.60

0.55

Allelic model

5196 / 4936

1.17

1–1.37 (0.04)

76.7

< 0.001

−1.72

0.08

−1.04

0.30

TT vs. CC

5196 / 4936

1.34

1.13–1.58 (< 0.001)

42.7

0.01

−1.48

0.13

−1.15

0.40

CT vs. CC

5196 / 4936

1

0.70–1.42 (0.97)

75.1

< 0.001

−2

0.04

−1.42

0.20

 Europe

Dominant model

1704 / 2347

1.46

1.15–1.85 (< 0.001)

56.9

0.01

0

1

−0.70

0.49

Recessive model

1704 / 2347

1.35

0.98–1.86 (0.06)

0

0.94

− 1.58

0.11

−1.91

0.08

Allelic model

1704 / 2347

1.34

1.12–1.61 (< 0.001)

51

0.02

−1.03

0.30

−1.50

0.16

TT vs. CC

1704 / 2347

1.53

1.10–2.14 (0.01)

0

0.80

0.16

0.87

−0.87

0.40

CT vs. CC

1704 / 2347

1.44

1.13–1.83 (< 0.001)

55.6

0.01

0.78

0.43

0.33

0.74

 America

Dominant model

1991 / 1828

1.22

0.95–1.58 (0.11)

54.5

0.01

−1.33

0.27

−2.05

0.07

Recessive model

1991 / 1828

1.15

0.96–1.39 (0.12)

24.3

0.22

−1.34

0.18

0.99

0.35

Allelic model

1991 / 1828

1.19

0.99–1.44 (0.06)

64.8

< 0.001

− 0.98

0.32

−0.48

0.64

TT vs. CC

1991 / 1828

1.27

0.98–1.64 (0.07)

43.7

0.06

− 1.52

0.12

−1.91

0.09

CT vs. CC

1991 / 1828

1.18

0.94–1.48 (0.15)

39.3

0.09

−1.52

0.12

−1.94

0.08

 East-Asian

Dominant model

4246 / 3908

1.43

1.14–1.79 (< 0.001)

26.3

0.14

−1.08

0.28

1.53

0.29

Recessive model

4246 / 3908

1.14

1.03–1.26 (< 0.001)

66.6

< 0.001

−1.02

0.27

−1.51

0.36

Allelic model

4246 / 3908

1.29

1.10–1.52 (< 0.001)

72

< 0.001

−1.79

0. 58

−3.10

0.06

TT vs. CC

4246 / 3908

1.33

1.11–1.59 (< 0.001)

41.8

0.02

−1.27

0.29

−1.39

0.31

CT vs. CC

4246 / 3908

1.24

1.00–1.53 (0.04)

0

0.74

−1.89

0.68

−1.71

0.10

 Non-East-Asian

Dominant model

5333 / 5973

1.10

0.90–1.36 (0.35)

77.4

< 0.001

−0.80

0.42

−1.18

0.35

Recessive model

5333 / 5973

1.25

1.08–1.45 (< 0.001)

21.9

0.14

0.59

0.55

0.73

0.47

Allelic model

5333 / 5973

1.15

1–1.32 (0.04)

71.5

< 0.001

−1.05

0.48

−1.82

0.07

TT vs. CC

5333 / 5973

1.34

1.12–1.61 (< 0.001)

24

0.11

−0.37

0.70

−1.04

0.30

CT vs. CC

5333 / 5973

1.03

0.83–1.28 (0.78)

77.9

< 0.001

−1.16

0.24

−1.93

0.06

 Caucasian

Dominant model

7360 / 7971

1.30

1.12–1.51 (< 0.001)

49.2

< 0.001

−1.04

0.48

−1.51

0.18

Recessive model

7360 / 7971

1.16

1.06–1.27 (< 0.001)

49.7

< 0.001

−1.31

0.24

−2.77

0.09

Allelic model

7360 / 7971

1.25

1.12–1.39 (< 0.001)

65

< 0.001

1.40

0.17

−1.12

0.38

TT vs. CC

7360 / 7971

1.34

1.16–1.56 (< 0.001)

24.9

0.09

−1.52

0.16

−1.34

0.29

CT vs. CC

7360 / 7971

1.22

1.05–1.42 (< 0.001)

39.6

< 0.001

−1.54

0.12

−1.80

0.08

 Arab

Dominant model

316 / 284

0.36

0.07–1.88 (0.22)

91.5

< 0.001

0.68

0.49

−0.17

0.83

Recessive model

316 / 284

1.53

0.27–1.48 (0.09)

87.4

< 0.001

0

1

−1.67

0.19

Allelic model

316 / 284

0.63

0.67–3.68 (0.29)

85.4

< 0.001

0.49

0.62

−0.11

0.92

TT vs. CC

316 / 284

0.93

0.43–1.99 (0.85)

66.6

0.02

0.68

0.49

1.25

0.33

CT vs. CC

316 / 284

0.29

0.05–1.84 (0.19)

92.3

< 0.001

0

1

−0.71

0.55

 African-American

Dominant model

1903 / 1626

1.34

1.07–1.67 (0.01)

35.3

0.13

−1.67

0.09

1.97

0.27

Recessive model

1903 / 1626

1.18

0.98–1.43 (0.07)

24.7

0.22

0.63

0.53

1.11

0.30

Allelic model

1903 / 1626

1.25

1.04–1.50 (0.01)

58.9

0.01

−1.46

0.14

−0.81

0.44

TT vs. CC

1903 / 1626

1.37

1.04–1.80 (0.02)

36.2

0.12

−1.67

0.09

−1.44

0.40

CT vs. CC

1903 / 1626

1.30

1.06–1.58 (0.01)

13.9

0.31

−1.67

0.09

−1.46

0.41