Fig. 3

The distribution of NK cell counts and percentages in AAV. a, b HC, n = 120 healthy controls; AAV, n = 357 measurements in 95 AAV patients. The Kolmogorov-Smirnov test revealed different distributions of NK cell counts (a) and percentages (b) in AAV compared to HC (###, p < 0.0001; ##, p = 0.0018). The medians were compared using Mann Whitney test (***, p < 0.0001; NS, not significant). The middle graphs show the cumulative relative frequencies and the right graphs the actual relative frequencies as histograms, respectively; the bin width was 50 counts/μl and 5%, respectively. In c, the course of three patients with GPA, MPA and EGPA over several consecutive measurements (1 to 9) are shown to demonstrate examples of intra-individual variability of NK cell counts (left) and percentages (right). All data derived from vasculitis center 1