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Table 5 Associations of HOMA-IR levels in SVR patients at 24 weeks post-therapy

From: Critical role of triglycerides for adiponectin levels in hepatitis C: a joint study of human and HCV core transgenic mice

24-week post-therapy factors

Univariate analyses

Multivariate analyses

 

95% CI of β (β)

p values

95% CI of β (β)

p values

Male, yes

− 0.2028 to 1.232 (0.515)

0.158

  

Age, (years)

− 0.041 to 0.015 (− 0.013)

0.354

  

BMI (kg/m2)

0.184–0.358 (0.271)

 < 0.001

0.094–0.335 (0.215)

0.001

ALT (U/L)

0.049–0.094 (0.071)

 < 0.001

0.018–0.078 (0.048)

0.002

eGFR (mL/min/1.73 m2)

− 0.0024 to 0.025 (0.011)

0.102

  

TG (mg/dL)

0.006–0.014 (0.01)

 < 0.001

0.000–0.01 (0.005)

0.057

TC (mg/dL)

− 0.015 to 0.004 (− 0.005)

0.271

  

Adiponectin (μg/mL)

− 0.22 to 0.064 (− 0.078)

0.283

  

Uric acid (mg/dL)

− 0.1046 to 0.466 (0.181)

0.212

  

NLR

− 6.116 to 4.889 (− 0.613)

0.391

  

Platelet (103/uL)

− 0.013 to 0.00 (− 0.007)

0.059

− 0.013 to 0.002 (− 0.005)

0.145

Liver cirrhosis, yes

0.12–1.789 (0.954)

0.025

− 1.000 to 1.253 (0.126)

0.825

Fibrosis-4 score

− 0.069 to 0.263 (0.097)

0.252

  

Ferritin (ng/mL)

0.001–0.004 (0.002)

0.001

0.000–0.003 (0.001)

0.092

IFNL3-rs12979860

CC genotype, yes

− 1.875 to 0.318 (− 0.778)

0.163

  
  1. HOMA-IR: homeostatic model assessment for insulin resistance; SVR: sustained virological response; BMI: body mass index; HCV: hepatitis C virus; RNA: ribonucleic acid; ALT: alanine transaminase; eGFR: estimated glomerular filtration rate; TG: triglycerides; TC: total cholesterol; NLR: neutrophil lymphocyte ratio; IFNL3; interferon-λ3