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Table 4 IgG subclasses as percentages of IgGsuma

From: Factors associated with IgG levels in adults with IgG subclass deficiency

Subjects

IgG1, %c

IgG2, %d

IgG3, %e

IgG4, %f

Reference

Adults with IgGSD and subnormal IgG1 alone

(n = 39)

50.2 ± 8.3

37.9 ± 8.7

8.1 (5.2, 17.3)

2.0 (0.2, 11.7)

Present study

Ratios of subclasses compared to IgG4

25.1

19.0

4.1

1.0

 

Adults with IgGSD and combined subnormal IgG1/IgG3 (n = 53)

49.2 ± 8.4

42.8 ± 9.1

4.3 (1.7, 7.1)

2.7 (0.2, 9.6)

Present study

Ratios of subclasses compared to IgG4

18.2

15.9

1.6

1.0

 

Adults with IgGSD and subnormal IgG3 alone (n = 115)b

61.3 ± 8.1

32.7 ± 8.1

2.9 (0.7, 5.4)

2.4 (0.1, 12.4)

Present study

Ratios of subclasses compared to IgG4

25.5

13.6

1.2

1.0

 

Normal adults (n = 108)b

62.8

30.5

2.4

4.4

[28]

Ratios of subclasses compared to IgG4

14.3

6.9

0.5

1.0

 

Laboratory personnel (n = 107)b

58.4

31.3

5.4

4.9

[29]

Ratios of subclasses compared to IgG4

11.9

6.4

1.1

1.0

 

Healthy adults (n = 172)b

60.3

31.0

6.2

2.5

[2]

Ratios of subclasses compared to IgG4

24.1

12.4

2.5

1.0

 

Blood donors (n = 100)b

61.7

30.3

5.7

2.3

[30]

Ratios of subclasses compared to IgG4

26.8

13.2

2.5

1.0

 
  1. Each row of italics corresponds to the non-italics font entries above
  2. aIgGsum = sum of subclass levels (IgG1 + IgG2 + IgG3 + IgG4); IgGSD, Ig subclass deficiency. Data from the present study are expressed as mean ± 1 SD or median (range) of individual IgG subclass measurements as proportions of IgGsum (± 1 standard deviation)
  3. bData cited from the literature are expressed as the aggregate mean IgG subclass level as a proportion of the sum of aggregate mean total IgG subclass (IgG1 + IgG2 + IgG3 + IgG4) values
  4. cMean percent IgG1 in both subnormal IgG1 subclass groups is lower than mean percent IgG1 in subnormal IgG3 group (p < 0.0001, both comparisons). The difference in mean percent IgG1 between the two subnormal IgG1 subclass groups is not significant (p = 0.5856)
  5. dMean percent IgG2 in subnormal IgG1 only group is lower than mean percent IgG2 in combined subnormal IgG1/IgG3 group (p = 0.0106). Mean percent IgG2 in subnormal IgG3 group is lower than mean percent IgG2 in either subnormal IgG1 subclass group (p < 0.0001, both comparisons)
  6. eMedian percent IgG3 is higher in subnormal IgG1 group than median percent IgG3 in combined subnormal IgG1/IgG3 or subnormal IgG3 groups (p < 0.0001, both comparisons). Median percent IgG3 in combined subnormal IgG1/IgG3 group is higher than that in subnormal IgG3 group (p < 0.0001)
  7. fMedian percent IgG4 is lower in subnormal IgG1 group than in combined subnormal IgG1/IgG3 group (p = 0.0377). There is no significant difference in median percent IgG in subnormal IgG1 only and subnormal IgG3 only groups (p = 0.4634). Median percent IgG4 in combined subnormal IgG1/IgG3 group is higher than that in subnormal IgG3 group (p = 0.0453)
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BMC Immunology

ISSN: 1471-2172

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