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Table 2 Clinical characteristics of rheumatoid arthritis (RA) patients with or without interstitial lung disease (ILD)

From: Soluble programmed death molecule 1 (sPD-1) as a predictor of interstitial lung disease in rheumatoid arthritis

  RA-ILD (n = 58) RA-non-ILD (n = 29) P value
Age (years, mean ± SD) 65.7 ± 9.4 61.8 ± 9.2 0.096
Female, (n,%) 36 (62.1) 25 (86.2) 0.02*
Disease duration (months), median, IQR 60 (19.5,120) 72 (5.5,46.5) 0.772
Smoker, (n, %) 15(25.9) 1(3.4) 0.011*
Serum immunology
 Anti-CCP positive, n, %) 54 (93.1) 21 (75.0) 0.008*
 Anti-CCP titer(RU/ml), mean ± SD 696.9 ± 531.4 429.3 ± 555.8 0.004*
 RF positive, (n, %) 51(87.9) 22(75.9) 0.148
 RF titer (IU/ml), mean ± SD 615.8 ± 1186.5 213.8 ± 194.9 0.289
 ANA positive, (n, %) 29 (50.0) 14 (48.3) 0.879
 Anti-ds-DNA, (n, %) 0 (0.0) 1 (3.4) 0.155
 Anti-SSA, (n, %) 7 (12.1) 1 (3.4) 0.197
 Anti-Ro52, (n, %) 9 (15.5) 4 (13.8) 0.832
 Anti-PM-Scl, (n, %) 0 (0.0) 1(3.4) 0.155
 Anti-RNP, (n, %) 1 (1.7) 0(3.4) 0.481
 Anti-centromere, (n, %) 2 (3.4) 0 (0.0) 0.312
 Anti-phospholipid, (n, %) 4 (6.9) 2 (6.9) > 0.99
 ANCA, (n, %) 4 (6.9) 5 (17.2) 0.135
Disease activity and treatment
 CRP (mg/dl), mean ± SD 32.8 ± 44.3 39.2 ± 35.5 0.109
 ESR (mm/h), mean ± SD 54.2 ± 34.3 47.1 ± 30.6 0.716
 IgG (g/L), mean ± SD 13.67 ± 4.42 13.31 ± 3.06 0.642
 Ferritin (ng/L), mean ± SD 213.4 ± 128.7 188.2 ± 180.5 0.341
 DAS28-ESR, mean ± SD 4.8 ± 1.5 4.7 ± 1.2 0.739
 Sharp score, mean ± SD 18.4 ± 22.2 29.8 ± 24.7 0.099
 Use of biologics, (n, %) 11 (18.9) 0 (0) 0.012*
 Use of MTX, (n, %) 10 (17.2) 18 (62.1) < 0.0001*
 Use of GCs, (n, %) 45 (77.6) 16 (55.2) 0.03*
 Dose of GCs (mg/day), mean ± SD 13.9 ± 12.8 7.6 ± 7.6 0.024*
  1. sPD-1 soluble programmed death molecule-1, anti-CCP anticitrullinated peptide antibody, RF rheumatoid factor, ANA antinuclear antibody, Anti-ds-DNA Anti-double-stranded DNA, ANCA anti-neutrophil cytoplasmic antibody, CRP C-reactive protein, ESR erythrocyte sedimentation rate, IgG immunoglobulin G, DAS28 disease activity score using 28 joint counts, MTX methotrexate, GCs glucocorticoids (in prednisolone equivalent)
  2. –: NA; *P < 0.05