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Table 4 Comparison of clinical characteristics of RA-ILD patients with different levels of sPD-1

From: Soluble programmed death molecule 1 (sPD-1) as a predictor of interstitial lung disease in rheumatoid arthritis

  sPD-1 P value
High-level group
n = 34
Low-level group
n = 24
Age (years, mean ± SD) 66.0 ± 9.7 65.2 ± 9.0 0.689
Female, (n, %) 22 (64.7) 15 (62.5) 0.863
Disease duration (months), median, IQR 60 (12, 141) 60 (36, 120) 0.548
Smoking history, (n, %) 9 (26.5) 5 (20.8) 0.621
RF titer (IU/ml), mean ± SD 538.8 ± 1151.9 542.8 ± 928.1 0.989
Anti-CCP positive, mean ± SD 32 (94.1) 22 (91.7) 0.717
ESR (mm/h), mean ± SD 48.9 ± 34.1 53.5 ± 31.4 0.60
CRP (mg/dl), mean ± SD 36.0 ± 51.1 29.3 ± 33.9 0.549
DAS28-ESR, mean ± SD 4.5 ± 1.3 5.2 ± 1.7 0.105
HRCT score, mean ± SD 6.2 ± 3.1 5.3 ± 3.7 0.319
CT-UIP (n, %) 23(67.6) 11(45.8) 0.096
FVC%, mean ± SD 82.5 ± 20.1 94.8 ± 15.2 0.022*
DLCO%, mean ± SD 58.4 ± 15.5 66.2 ± 20.6 0.201
Cough (n, %) 21 (61.8) 10 (41.7) 0.131
Dyspnea (n, %) 6 (17.6) 3 (12.5) 0.722
Chest tightness (n, %) 14 (41.2) 6 (25.0) 0.202
Use of GCs (n, %) 23 (67.6) 21 (87.5) 0.121
Use of MTX (n, %) 6 (17.6) 3 (12.5) 0.722
  1. sPD-1 soluble programmed death molecule-1, ESR erythrocyte sedimentation rate, CRP C-reactive protein, DAS28 disease activity score using 28 joint counts, HRCT high resolution computerized tomography, UIP usual interstitial pneumonitis, RF rheumatoid factor, anti-CCP anticitrullinated peptide antibody, MTX methotrexate, GCs glucocorticoids (in prednisolone equivalent)