Table 2 All the identified and validated hub genes in the datasets. True hub genes were defined as verified ones in two other IgAN datasets
No | All hub genes | Modules | MDa (GSE104948) | VD1b (GSE93798) | VD2c (GSE37460) | True hub genes |
|---|---|---|---|---|---|---|
1 | Colony stimulating factor 1 receptor (CSF1R) | Blue | ✓ | ✓ | ✓ | ✓ |
2 | Cytochrome b-245 beta chain (CYBB) | Blue | ✓ | ✓ | ✓ | ✓ |
3 | TYRO protein tyrosine kinase binding protein (TYROBP) | Blue | ✓ | ✓ | ✓ | ✓ |
4 | integrin subunit beta 2 (ITGB2) | Blue | ✓ | ✓ | ✓ | ✓ |
5 | Toll-like receptor 1 (TLR1) | Blue | ✓ | ✓ | ✓ | ✓ |
6 | Toll-like receptor 2 (TLR2) | Blue | ✓ | ✓ | ✓ | ✓ |
7 | CD44 | Blue | ✓ | ✓ | ✓ | ✓ |
8 | Proteasome 20S subunit beta 9 (PSMB9) | Black | ✓ | ✓ | ✓ | ✓ |
9 | G protein subunit gamma 11 (GNG11) | Black | ✓ | ✓ | ✓ | ✓ |
10 | Platelet and endothelial cell adhesion molecule 1 (PECAM1) | Black | ✓ | ✓ | ✓ | ✓ |
11 | DNA methyltransferase 1 (DNMT1) | Red | ✓ | ✓ | ✓ | ✓ |
12 | RNA polymerase II subunit G (POLR2G) | Red | ✓ | - | - | - |
13 | Proteasome 26S subunit, non-ATPase 4 (PSMD4) | Red | ✓ | ✓ | - | - |
14 | Tight junction protein 1 (TJP1) | Brown | ✓ | - | ✓ | - |
15 | FYN proto-oncogene (FYN) | Brown | ✓ | - | ✓ | - |
16 | Interleukin 13 (IL13) | Magenta | ✓ | - | ✓ | - |