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Table 1 Demographic and clinical characteristics of patients

From: Oxidative stress-related circulating miRNA-27a is a potential biomarker for diagnosis and prognosis in patients with sepsis

 

Total (N = 48)

Non-sepsis (n = 25)

Sepsis (n = 23)

p-value

Age (years), median (range)

65 (37–92)

58 (37–91)

65 (40–92)

0.200

Sex, n (%)

   

1.000

 Male

27 (56.3%)

14 (56.0%)

13 (56.5%)

 

 Female

21 (43.8%)

11 (44.0%)

10 (43.5%)

 

Hypertension, n (%)

16 (33.3%)

9 (36.0%)

7 (30.4%)

0.765

CVD, n (%)

1 (2.1%)

1 (4.0%)

0 (0.0%)

1.000

DM, n (%)

10 (20.8%)

5 (20.0%)

5 (21.7%)

1.000

APACHE II score, median (range)

22 (4–32)

20 (4–32)

25 (17–32)

0.017*

SOFA score, median (range)

8 (2–24)

4 (2–24)

12 (5–21)

 < 0.001*

Infectious shock, n (%)

15 (31.3%)

0 (0.0%)

15 (65.2%)

 < 0.001*

Multiple organ failure, n (%)

5 (10.4%)

0 (0.0%)

5 (21.7%)

0.020*

CRP (mg/L), median (range)

241.5 (4.9–365.9)

167.0 (4.9–365.9)

257.3 (36.4–355.8)

0.040*

PCT (ng/mL), median (range)

21.8 (0.1–100.0)

2.3 (0.1–85.0)

62.3 (3.9–100.0)

 < 0.001*

WBC (× 109/L), median (range)

16.8 (2.3–61.7)

15.5 (4.7–37.3)

19.9 (2.3–61.7)

0.044*

MDA (nmol/mL), median (range)

29.4 (0.6–361.7)

11.8 (0.6–361.7)

51.8 (2.6–263.9)

0.011*

SOD (U/mL), median (range)

22.0 (0.3–118.9)

40.3 (0.3–118.9)

20.3 (3.3–101.2)

0.040*

GSH-Px (IU), median (range)

1583.0 (555.6–3787.8)

2350.4 (555.6–3737.4)

1479.2 (638.9–3787.8)

 < 0.001*

MiR-27a, median (range)

1.0 (0.1–3.5)

0.7 (0.1–2.1)

1.2 (0.2–3.5)

0.010*

28-day mortality, n (%)

25 (52.1%)

9 (36.0%)

16 (69.6%)

0.025*

ICU stay, median (range)

9 (1–71)

13 (2–71)

8 (1–48)

0.230

Hospital stat, median (range)

16 (1–71)

19 (2–71)

13 (1–54)

0.160

  1. CVD, cardiovascular disease; CRP, C-reactive protein; PCT, procalcitonin; WBC, white blood cell; APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment; SOD, superoxide dismutase; MDA, Malondialdehyde; GSH-Px, glutathione peroxidase
  2. *p < 0.05