Table 2 The correlation analysis between EZH2 and related immune cell genes and markers of immune cells in TIMER
From: The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma
Immune cell | Gene markers | None | Purity | ||
|---|---|---|---|---|---|
Cor | P-value | Cor | P-value | ||
CD8 + T cell | CD8A | 0.180 | ** | 0.286 | *** |
CD8B | 0.160 | * | 0.272 | *** | |
T cell | CD6 | 0.161 | * | 0.305 | *** |
CD3D | 0.235 | *** | 0.350 | *** | |
CD3E | 0.161 | * | 0.214 | *** | |
SH2D1A | 0.147 | * | 0.265 | *** | |
TRAT1 | 0.141 | * | 0.267 | *** | |
CD3G | 0.226 | *** | 0.324 | *** | |
CD2 | 0.182 | ** | 0.323 | *** | |
B cell | CD19 | 0.244 | *** | 0.318 | *** |
FCRL2 | 0.173 | ** | 0.303 | *** | |
KIAA0125 | 0.118 | 0.023 | 0.226 | *** | |
TNFRSF17 | 0.130 | 0.012 | 0.264 | *** | |
SPIB | 0.373 | *** | 0.464 | *** | |
PNOC | 0.166 | * | 0.279 | *** | |
CD79A | 0.131 | 0.012 | 0.245 | *** | |
Monocyte | CD86 | 0.294 | *** | 0.449 | *** |
CD115(CSF1R) | 0.153 | * | 0.296 | *** | |
TAM | CD68 | 0.210 | *** | 0.301 | *** |
IL10 | 0.220 | *** | 0.335 | *** | |
M1 macrophage | IRF5 | 0.482 | *** | 0.487 | *** |
COX2(PTGS2) | 0.088 | 0.092 | 0.212 | *** | |
M2 macrophage | CD163 | 0.101 | 0.052 | 0.218 | *** |
MS4A4A | 0.102 | 0.051 | 0.231 | *** | |
Neutrophils | FPR1 | 0.218 | *** | 0.35 | *** |
SIGLEC5 | 0.271 | *** | 0.402 | *** | |
CSF3R | 0.285 | *** | 0.428 | *** | |
FCGR3B | 0.175 | ** | 0.206 | ** | |
CEACAM3 | 0.16 | 0.041 | 0.186 | ** | |
CD116(ITGAM) | 0.289 | *** | 0.387 | *** | |
Dendritic cell | CCL13 | 0.137 | * | 0.196 | ** |
CD209 | 0.127 | 0.014 | 0.212 | *** | |
HSD11B1 | 0.332 | *** | − 0.336 | *** | |
HLA-DPB1 | 0.154 | * | 0.271 | *** | |
HLA-DQB1 | 0.146 | * | 0.256 | *** | |
HLA-DRA | 0.167 | * | 0.287 | *** | |
HLA-DPA1 | 0.158 | * | 0.283 | *** | |
BCDA-1(CD1C) | 0.114 | 0.029 | 0.207 | ** | |
BDCA-4(NRP1) | 0.263 | *** | 0.291 | *** | |
CD11c(ITGAX) | 0.348 | *** | 0.484 | *** | |
Natural killer cell | XCL2 | 0.17 | ** | 0.258 | *** |
KIR2DL1 | 0.039 | 0.455 | 0.018 | 0.742 | |
KIR2DL3 | 0.168 | * | 0.205 | ** | |
KIR2DL4 | 0.211 | *** | 0.241 | *** | |
Mast cell | TPSB2 | − 0.037 | 0.479 | 0.001 | 0.986 |
HDC | − 0.149 | * | − 0.121 | 0.025 | |
Th1 | IFN-γ(IFNG) | 0.249 | *** | 0.333 | *** |
TNF-α(TNF) | 0.282 | *** | 0.414 | *** | |
STAT4 | 0.238 | *** | 0.303 | *** | |
STAT1 | 0.387 | *** | 0.246 | *** | |
Th2 | GATA3 | 0.172 | ** | 0.309 | *** |
STAT6 | 0.193 | ** | 0.179 | ** | |
STAT5A | 0.329 | *** | 0.389 | *** | |
Tfh | BCL6 | 0.201 | *** | 0.205 | ** |
IL21 | 0.147 | * | 0.188 | ** | |
Th17 | STAT3 | 0.168 | * | 0.209 | *** |
IL17A | 0.072 | 0.168 | 0.075 | 0.164 | |
Effector T cell | CX3CR1 | 0.187 | ** | 0.242 | *** |
FGFBP2 | − 0.085 | 0.103 | − 0.07 | 0.195 | |
FCGR3A | 0.295 | *** | 0.383 | *** | |
Effector memory T cell | PD-1 (PDCD1) | 0.295 | *** | 0.391 | *** |
DUSP4 | 0.256 | *** | 0.363 | *** | |
Central memory T cell | CCR7 | 0.083 | 0.111 | 0.219 | *** |
SELL | 0.196 | ** | 0.308 | *** | |
IL7R | 0.093 | 0.073 | 0.201 | ** | |
Resident memory T cell | CD69 | 0.109 | 0.035 | 0.222 | *** |
ITGAE | 0.279 | *** | 0.280 | *** | |
CXCR6 | 0.156 | * | 0.288 | *** | |
MYADM | 0.354 | *** | 0.388 | *** | |
Exhausted T cell | TIM-3 (HAVCR2) | 0.310 | *** | 0.472 | *** |
TIGIT | 0.262 | *** | 0.385 | *** | |
LAG3 | 0.287 | *** | 0.332 | *** | |
CXCL13 | 0.264 | *** | 0.342 | *** | |
LAYN | 0.185 | ** | 0.257 | *** | |
Resting treg T cell | FOXP3 | 0.191 | ** | 0.262 | *** |
IL2RA | 0.252 | *** | 0.377 | *** | |
Effector treg T cell | CTLA4 | 0.296 | *** | 0.404 | *** |
CCR8 | 0.383 | *** | 0.479 | *** | |