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Table 2 The correlation analysis between EZH2 and related immune cell genes and markers of immune cells in TIMER

From: The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma

Immune cell Gene markers None Purity
Cor P-value Cor P-value
CD8 + T cell CD8A 0.180 ** 0.286 ***
CD8B 0.160 * 0.272 ***
T cell CD6 0.161 * 0.305 ***
CD3D 0.235 *** 0.350 ***
CD3E 0.161 * 0.214 ***
SH2D1A 0.147 * 0.265 ***
TRAT1 0.141 * 0.267 ***
CD3G 0.226 *** 0.324 ***
CD2 0.182 ** 0.323 ***
B cell CD19 0.244 *** 0.318 ***
FCRL2 0.173 ** 0.303 ***
KIAA0125 0.118 0.023 0.226 ***
TNFRSF17 0.130 0.012 0.264 ***
SPIB 0.373 *** 0.464 ***
PNOC 0.166 * 0.279 ***
CD79A 0.131 0.012 0.245 ***
Monocyte CD86 0.294 *** 0.449 ***
CD115(CSF1R) 0.153 * 0.296 ***
TAM CD68 0.210 *** 0.301 ***
IL10 0.220 *** 0.335 ***
M1 macrophage IRF5 0.482 *** 0.487 ***
COX2(PTGS2) 0.088 0.092 0.212 ***
M2 macrophage CD163 0.101 0.052 0.218 ***
MS4A4A 0.102 0.051 0.231 ***
Neutrophils FPR1 0.218 *** 0.35 ***
SIGLEC5 0.271 *** 0.402 ***
CSF3R 0.285 *** 0.428 ***
FCGR3B 0.175 ** 0.206 **
CEACAM3 0.16 0.041 0.186 **
CD116(ITGAM) 0.289 *** 0.387 ***
Dendritic cell CCL13 0.137 * 0.196 **
CD209 0.127 0.014 0.212 ***
HSD11B1 0.332 *** − 0.336 ***
HLA-DPB1 0.154 * 0.271 ***
HLA-DQB1 0.146 * 0.256 ***
HLA-DRA 0.167 * 0.287 ***
HLA-DPA1 0.158 * 0.283 ***
BCDA-1(CD1C) 0.114 0.029 0.207 **
BDCA-4(NRP1) 0.263 *** 0.291 ***
CD11c(ITGAX) 0.348 *** 0.484 ***
Natural killer cell XCL2 0.17 ** 0.258 ***
KIR2DL1 0.039 0.455 0.018 0.742
KIR2DL3 0.168 * 0.205 **
KIR2DL4 0.211 *** 0.241 ***
Mast cell TPSB2 − 0.037 0.479 0.001 0.986
HDC − 0.149 * − 0.121 0.025
Th1 IFN-γ(IFNG) 0.249 *** 0.333 ***
TNF-α(TNF) 0.282 *** 0.414 ***
STAT4 0.238 *** 0.303 ***
STAT1 0.387 *** 0.246 ***
Th2 GATA3 0.172 ** 0.309 ***
STAT6 0.193 ** 0.179 **
STAT5A 0.329 *** 0.389 ***
Tfh BCL6 0.201 *** 0.205 **
IL21 0.147 * 0.188 **
Th17 STAT3 0.168 * 0.209 ***
IL17A 0.072 0.168 0.075 0.164
Effector T cell CX3CR1 0.187 ** 0.242 ***
FGFBP2 − 0.085 0.103 − 0.07 0.195
FCGR3A 0.295 *** 0.383 ***
Effector memory T cell PD-1 (PDCD1) 0.295 *** 0.391 ***
DUSP4 0.256 *** 0.363 ***
Central memory T cell CCR7 0.083 0.111 0.219 ***
SELL 0.196 ** 0.308 ***
IL7R 0.093 0.073 0.201 **
Resident memory T cell CD69 0.109 0.035 0.222 ***
ITGAE 0.279 *** 0.280 ***
CXCR6 0.156 * 0.288 ***
MYADM 0.354 *** 0.388 ***
Exhausted T cell TIM-3 (HAVCR2) 0.310 *** 0.472 ***
TIGIT 0.262 *** 0.385 ***
LAG3 0.287 *** 0.332 ***
CXCL13 0.264 *** 0.342 ***
LAYN 0.185 ** 0.257 ***
Resting treg T cell FOXP3 0.191 ** 0.262 ***
IL2RA 0.252 *** 0.377 ***
Effector treg T cell CTLA4 0.296 *** 0.404 ***
CCR8 0.383 *** 0.479 ***
  1. Cor, R-value of Spearman correlation; Purity, tumor purity-adjusted correlation. None, correlation without adjustment. *P < 0.01; **P < 0.001; ***P < 0.0001