The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma

Wu, Shi-yi; Xie, Zhao-yu; Yan, Lu-yu; Liu, Xiao-fang; Zhang, Yue; Wang, Da-an; Dong, Jie; Sun, Hong-tao

doi:10.1186/s12865-022-00502-7

BMC Immunology

Table 3 Correlation analysis between EZH2 markers of immune cells in GEPIA2

From: The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma

Immune cell	Gene markers	Tumor		Tumor-sum		Normal		Normal-sum
Immune cell	Gene markers	Cor	P-value	Cor	P-value	Cor	P-value	Cor	P-value
CD8 + T cell	CD8A	0.2	***	0.18	**	0.71	***	0.69	***
CD8 + T cell	CD8B	0.15	***			0.62	***
T cell	CD6	0.029	0.11	0.17	*	0.49	**	0.71	***
	CD3D	0.23	***			0.65	***
	CD3E	0.13	0.01			0.59	***
	SH2D1A	0.13	0.011			0.68	***
	TRAT1	0.034	0.51			0.65	***
	CD3G	0.24	***			0.63	***
	CD2	0.15	*			0.52	**
B cell	CD19	0.11	0.03	0.21	***	0.39	*	0.36	***
	FCRL2	0.076	0.14			0.57	***
	KIAA0125	0.15	*			0.53	***
	TNFRSF17	0.094	0.071			0.6	***
	SPIB	0.14	*			0.43	*
	PNOC	0.1	0.047			0.59	***
	CD79A	0.083	0.11			0.51	**
Monocyte	CD86	0.32	***	0.27	***	0.55	***	0.55	***
Monocyte	CD115(CSF1R)	0.22	***			0.49	**
TAM	CD68	0.23	***	0.26	***	0.53	***	0.57	***
TAM	IL10	0.21	***			0.43	*
M1 Macrophage	IRF5	0.44	***	0.37	***	0.44	*	0.44	*
M1 Macrophage	COX2(PTGS2)	0.035	0.5			0.27	0.055
M2 Macrophage	CD163	0.16	*	0.12	0.017	0.38	*	0.47	**
M2 Macrophage	MS4A4A	0.16	*			0.48	**
Neutrophils	FPR1	0.24	***	0.35	***	0.31	0.028	0.49	**
	SIGLEC5	0.27	***			0.17	0.24
	CSF3R	0.21	***			0.5	**
	FCGR3B	0.03	0.56			0.32	0.021
	CEACAM3	0.15	*			0.25	0.078
	CD116(ITGAM)	0.34	***			0.69	***
Natural killer cell	XCL2	0.049	0.35	0.15	*	0.67	***	0.6	***
	KIR2DL1	0.11	0.038			0.62	***
	KIR2DL3	0.21	***			0.22	0.12
	KIR2DL4	0.2	***			0.32	0.025
Dendritic cell	CCL13	0.065	0.22	0.068	0.19	0.41	*	0.64	***
	CD209	0.16	*			0.44	*
	HSD11B1	− 0.22	***			0.094	0.51
	HLA-DPB1	0.22	***			0.58	***
	HLA-DQB1	0.088	0.09			0.52	***
	HLA-DRA	0.22	***			0.59	***
	HLA-DPA1	0.2	**			0.54	***
	BCDA-1(CD1C)	0.17	**			0.63	***
	BDCA-4(NRP1)	0.28	***			0.41	*
	CD11c(ITGAX)	0.25	***			0.5	***
Mast cell	TPSB2	− 0.042	0.42	0.031	0.56	0.096	0.51	− 0.097	0.5
Mast cell	HDC	− 0.059	0.26			− 0.083	0.57
Th1	IFN-γ(IFNG)	0.21	***	0.29	***	0.65	***	0.84	***
	TNF-α(TNF)	0.11	.031			0.33	0.02
	STAT4	0.081	0.12			0.61	***
	STAT1	0.21	***			0.8	***
Th2	GATA3	0.18	**	0.29	***	0.19	0.19	0.62	***
	STAT6	0.18	**			0.57	***
	STAT5A	0.22	***			0.69	***
Tfh	BCL6	0.1	0.054	0.17	**	0.011	0.94	0.11	0.46
Tfh	IL21	0.12	0.023			0.31	0.031
Th17	STAT3	0.29	***	0.26	***	0.11	0.44	0.2	0.16
Th17	IL17A	0.0028	0.96			0.25	0.085
Effector T cell	CX3CR1	0.14	*	0.27	***	0.22	0.13	0.45	*
	FGFBP2	− 0.098	0.06			0.074	0.61
	FCGR3A	0.29	***			0.5	***
Effector memory T cell	PD-1 (PDCD1)	0.22	***	0.39	***	0.73	***	0.72	***
Effector memory T cell	DUSP4	0.29	***			0.54	***
Central memory T cell	CCR7	0.064	0.22	0.12	0.023	0.58	***	0.68	***
	SELL	0.12	0.024			0.54	***
	IL7R	0.029	0.58			0.56	***
Resident memory T cell	CD69	0.039	0.46	0.28	***	0.63	***	0.64	***
	ITGAE	0.23	***			0.092	0.52
	CXCR6	0.14	*			0.44	*
	MYADM	0.29	***			0.24	0.1
Exhausted T cell	TIM-3(HAVCR2)	0.13	0.014	0.3	***	0.53	***	0.65	***
	PD-1 (PDCD1)	0.22	***			0.73	***
	TIGIT	0.22	***			0.61	***
	LAG3	0.2	**			0.48	**
	CXCL13	0.097	0.064			0.31	0.028
	LAYN	0.087	0.095			0.52	***
Resting treg T cell	FOXP3	− 0.002	0.96	0.15	*	0.42	*	0.6	***
Resting treg T cell	IL2RA	0.19	**			0.37	*
Effector treg T cell	CTLA4	0.23	***	0.25	***	0.65	***	0.68	***
	CCR8	0.21	***			0.51	**
	TNFRSF9	0.015	0.77			0.65	***

Tumour, correlation analysis in tumour tissue of TCGA; Normal, correlation analysis in normal tissue of TCGA. *P < 0.01; **P < 0.001; ***P < 0.0001

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