Fig. 5
From: Interleukin-22 protects from endotoxemia by inducing suppressive F4/80+Ly6GhiLy6Chi cells population
Pivotal function of F-652 in LPS-induced endotoxemia. In the LPS induced endotoxemia model, LPS are rapidly recognized by pathogen recognition receptors (PRRs), such as Toll-like receptor (TLR4), which can initiate highly specific pro-inflammatory signaling pathways, and release a lot of pro-inflammatory cytokines. F-652 can induced the expression of S100A9 in liver, and S100A9 induced M2 macrophages polarization to suppression of excessive inflammation