Fig. 2
From: Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer
Macrophages induced by PCa exosomes show characteristics similar to M2 cells. A Cytokine profiles of macrophages induced by PCa exosomes. After treatment of PCa exosomes, the concentration of IL-12, TNF-α, TGF-β1, and IL-10 secreted by macrophages was measured by ELISA. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. B PCa exosomes increased CD206 expression in macrophages. After THP1 cells were induced to macrophages with PMA, macrophages were co-cultured with PCa exosomes. The number of CD206+ macrophages was determined with an anti-CD-206-FITC (green) using a High Throughput Connotation of Imaging System (original magnification, 100×)